Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-60
SponsorXijing Hospital
About this trial
To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
The preoperative routine tests and examinations revealed no contraindications.
Revised sentence: "Informed consent of the patient
Disqualifiers
The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
In injection site or damage to the skin.
Patients with tumors or undergoing radiotherapy and chemotherapy.
Trial design
Design model
Parallel
Treatments tested in this trial
Sodium hyaluronate injection
DrugThe control group was injected into the joint cavity with sodium hyaluronate injection..
Treatment groups
300 Participants
are divided into 3 treatment groupsGroup A: PreoperativeNo intervention 0 interventions
Group B: postoperative (6 weeks)Experimental treatment 1 intervention
Group C: postoperative (3 months)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
X-ray
The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes.
Time frame
pre-operation,3 weeks after treatment, 6 months after treatment2
CT
The application of three-dimensional CT scan for the assessment of articular cartilage defects.
Time frame
pre-operation,3 weeks after treatment, 6 months after treatment3
MRI
The injury of ligaments, meniscus, and the knee joint was assessed using MRI.
Time frame
pre-operation,3 weeks after treatment, 6 months after treatmentSponsors and contacts
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Source ClinicalTrials.gov