Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

ConditionHeart Failure

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorFuture University in Egypt

About this trial

This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes.

The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital.

Some participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

>= 18 years, male or female EF <40%

Disqualifiers

EF>40% Pregnancy or breastfeeding

Trial population

The study population consists of adult patients with heart failure and reduced ejection fraction who are admitted to the cardiology wards at Mansoura University Hospital (MUH) during the study period. Participants include those who were already receiving ARNI therapy prior to hospital admission and those who were not, representing typical patients seen in clinical practice.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Prehospital ARNI use
Other intervention
Participants who were using ARNI therapy before hospital admission
No prehospital ARNI use
Other intervention
Participants who were not using ARNI therapy before hospital admission

Treatment groups

140 Participants

are divided into 2 treatment groups

Group A: Prehospital ARNI users1 intervention

Group B: Non-Prehospital ARNI users1 intervention

Trial outcomes

Primary outcomes

In-hospital cardiac and renal events

Time frame

3 months

Secondary outcomes

NYHA classification

Time frame

3 months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Future University in Egypt

Lead sponsor

Source ClinicalTrials.gov

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