Effect of Prostatic Urethra and Seminal Vesicle Morphometry on Ejaculation
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age18-55
SponsorBaşakşehir Çam & Sakura City Hospital
About this trial
The goal of this observational study is to learn whether the size and shape of the prostatic urethra and seminal vesicles - measured on multiparametric prostate MRI (mpMRI) - are related to premature ejaculation (PE) severity in men aged 18-55.
The main questions it aims to answer are:
* Do men with premature ejaculation have different prostatic urethral length and angulation compared to men without PE? * Do men with premature ejaculation have different seminal vesicle dimensions compared to men without PE? * Do prostatic urethra and seminal vesicle measurements on mpMRI correlate with PE severity scores (PEDT) and ejaculation latency time (IELT)?
Researchers will compare men with premature ejaculation to healthy men without ejaculatory complaints to see if specific anatomical features are associated with PE severity.
Participants will:
* Undergo a multiparametric prostate MRI that is already scheduled as part of their routine medical care * Complete validated questionnaires about ejaculation and sexual function (PEDT, PEP, IELT, IIEF-15) * Provide a blood sample for routine hormone level measurements
Eligibility criteria
This trial accepts healthy volunteersQualifiers
- Male aged 18 to 55 years
In a stable, heterosexual, monogamous relationship with the same female partner for at least 6 months
Normal erectile function defined as IIEF-15 erectile function domain score ≥26
Scheduled for clinically indicated multiparametric prostate MRI due to elevated PSA or hematospermia
Disqualifiers
Any major psychiatric or somatic disorder
Hormonal disorders such as hypothyroidism or hyperthyroidism
Erectile dysfunction (IIEF-15 erectile function domain score <26)
Age below 18 or above 55 years
Trial population
* Any major psychiatric or somatic disorder * Hormonal disorders such as hypothyroidism or hyperthyroidism * Erectile dysfunction (IIEF-15 erectile function domain score \<26) * Age below 18 or above 55 years
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
150 Participants
are grouped into 2 trial groupsGroup A: Premature Ejaculation
Group B: Control Group
Trial outcomes
Primary outcomes
1
Correlation Between Prostatic Urethral Length and Premature Ejaculation Severity
Pearson or Spearman correlation between prostatic urethral length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).
Time frame
At enrollment (single time point)2
Correlation Between Seminal Vesicle Dimensions and Premature Ejaculation Severity
Pearson or Spearman correlation between seminal vesicle anterior-posterior length and superior-anterior length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).
Time frame
At enrollment (single time point)3
Correlation Between Prostatic Urethral Angulation and Intravaginal Ejaculation Latency Time
Pearson or Spearman correlation between prostatic urethral angulation measured on mpMRI (degrees) and IELT (seconds). Lower IELT indicates greater PE severity.
Time frame
At enrollment (single time point)Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: