Effect of Raised End-Tidal pCo2 on Choroidal Volume
ConditionIntraocular Pressure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 8
SponsorUniversity of Pittsburgh
About this trial
This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
any child undergoing an eye exam under anesthesia for an ophthalmologic reason.
children between the ages newborn to 8 years of age.
Disqualifiers
children who are not having an eye exam under anesthesia.
children with a known medical diagnosis that affect the eye to be studied
* children over the age of 8 years of age.
* children with altered cerebral autoregulation, increased intracranial pressure, pulmonary hypertension, or any other condition deemed appropriate by the anesthesiologist.
Trial design
Design model
Single group
Treatments tested in this trial
Ventilation manipulation
Other interventionEffects of ventilation manipulation to achieve desired levels of end tidal carbon dioxide
Treatment groups
20 Participants
are divided into 1 treatment groupGroup A: Observational GroupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Intraocular Pressure (IOP) (mmHg)
Measurement of intraocular pressure after maintenance of end tidal pCO2 for 5 minutes at three end tidal pCO2 values : 40mmHg, then 30mmHg and then 50mmHg
Time frame
After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period IOP measuredSecondary outcomes
1
Choroidal thickness ( microns)
After 5 minutes of maintenance of end tidal pCO2 at 40mmHg, then 30mmHg and then 50mmHg, ocular coherence tomography (OCT) will be used to capture the subfoveal choroid. The images of the choroid will be provided to blinded individuals who will measure their thickness using the integrated scale on the OCT image.
Time frame
After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation;at the end of 5 minute period choroid images takenSponsors and contacts
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Source ClinicalTrials.gov