Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKonya City Hospital
About this trial
This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty. Adult patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia will be included. No additional intervention, drug administration, or biological sampling will be performed beyond standard clinical care.
Rebound pain will be assessed during the early postoperative period using pain diaries, numeric rating scale pain scores, and analgesic consumption records. Chronic postsurgical pain and related outcomes will be evaluated at postoperative 3 and 6 months using validated instruments assessing pain severity, neuropathic pain features, psychological status, functional outcomes, and health-related quality of life. The primary outcome is the presence of chronic postsurgical pain at 3 months after surgery. Secondary outcomes include chronic pain at 6 months, pain intensity, neuropathic pain characteristics, opioid consumption, rescue analgesic requirements, sleep disturbance, and quality-of-life measures. The study also aims to explore demographic and clinical factors associated with rebound pain and chronic postsurgical pain.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older
ASA physical status I to III
Scheduled for unilateral elective total knee arthroplasty
Planned to undergo spinal anesthesia
Disqualifiers
Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer)
Significant neuropathy or radiculopathy
Bilateral or two-stage total knee arthroplasty during the same hospitalization
Contralateral total knee arthroplasty within the previous 6 months
Trial population
Adult patients undergoing unilateral elective total knee arthroplasty at Konya City Hospital under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
220 Participants
are grouped into 2 trial groupsGroup A: Rebound Pain
Group B: No Rebound Pain
Trial outcomes
Primary outcomes
1
Presence of Chronic Postsurgical Pain at 3 Months
Chronic postsurgical pain will be defined as pain developing or persisting after total knee arthroplasty that is not explained by another cause. Participants with pain and at least one Brief Pain Inventory-Short Form interference item score of 3 or higher at postoperative month 3 will be considered positive for chronic postsurgical pain.
Time frame
3 months after surgerySecondary outcomes
1
Presence of Chronic Postsurgical Pain at 6 Months assessed by Brief Pain Inventory-Short Form (BPI-SF) interference score
Presence of chronic postsurgical pain at postoperative month 6 will be assessed using the same Brief Pain Inventory-Short Form (BPI-SF)-based study definition applied at month 3: pain not explained by another cause, NRS \>0, and at least one BPI-SF interference item score of 3 or higher.
Time frame
6 months after surgery2
Pain Intensity in the Early Postoperative Period
Pain intensity at rest and during movement will be assessed using the Numeric Rating Scale during the first 72 hours after surgery.
Time frame
0 to 72 hours after surgerySponsors and contacts
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Source ClinicalTrials.gov