This study is designed to evaluate the efficacy and safety of Recombinant Human Brain Natriuretic Peptide (rhBNP) in improving ventricular remodeling and cardiac function after acute anterior myocardial infarction undergoing percutaneous coronary intervention. 100 patients with acute anterior myocardial infarction after primary Percutaneous Coronary Intervention (pPCI) are randomly assigned 1:1 to rhBNP group(n=50) and control group(n=50) with follow-up of 24 weeks. Both groups are treated with standard therapy of AAMI, with the rhBNP group intravenous dripping rhBNP after pPCI for 3 days and the control group treated with placebo at the same time. The primary endpoint is the change in N terminal pro-B-type natriuretic peptide（NT-proBNP ）and cardiac troponin T(cTnT) level.The secondary endpoint is the change in 24-week echocardiographic including left ventricle ejection fraction (LVEF) , left ventricular end-diastolic volume index (LVEDVI) and left ventricular end-systolic volume index (LVESVI), arrhythmia and cardiovascular events (death, cardiac arrest or cardiopulmonary resuscitation, hospitalization due to heart failure or angina pectoris).
The first acute anterior myocardial infarction ( AMI ) within 12 hours ( or more than 12 hours but the ischemic symptoms continue ).
Age 18-75 years old, gender unlimited
Patients with acute anterior myocardial infarction undergoing emergency PCI within the effective time window
Successful reflow after interventional therapy ( TIMI = 3 ).
Patients with a history of coronary artery bypass grafting
Patients with cardiogenic shock
Patients with systolic blood pressure ( SBP ) ≤ 90 mmHg after treatment with vasopressors
Patients with mechanical complications ( ventricular septal perforation, mitral chordae rupture )
People who are about 18 to 75 years old get the first acute anterior myocardial infarction ( AMI ) within 12 hours ( or more than 12 hours but the ischemic symptoms continue ) and undergo emergency PCI within the effective time window,after which the blood reflows ( TIMI = 3 ).
Cohort
Prospective
Recombinant Human Brain Natriuretic Peptide
Drugwe divide our subjects into two groups;one is required to take recombinant human brain natriuretic peptide,the other is not required to take recombinant human brain natriuretic peptide
ultrasonic cardiogram：left ventricle ejection fraction (LVEF)
LVEF refers to the percentage of stroke output to left ventricular end-diastolic
ultrasonic cardiogram：left ventricular end-diastolic volume index (LVEDVI)
LVEDVI（ml/m2）=left ventricular end-diastolic volume（ml）/body surface area
ultrasonic cardiogram：left ventricular end-systolic volume index (LVESVI)
LVESVI（ml/m2）=left ventricular end-systolic volume（ml）/body surface area
N terminal pro-B-type natriuretic peptide（NT-proBNP ）decline level
NT-proBNP is a protein which is an "ingredient" for making the BNP hormone and a sign of heart failure can be obteined by blood
Adverse cardiovascular events
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