Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Aged ≥18 years
Stable clinical condition for >3 weeks (e.g., no exacerbations)
Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
Informed consent documented by signature
Severe daytime resting hypoxemia (SpO₂ <88%)
Long-term oxygen therapy
Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
Sequential
ambiant air
Other interventionStandard ambiant air will be breathed during endurance training. ambiant air
Oxygen
Other interventionSSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
ambiant air
Other interventionStandard ambiant air will be breathed during endurance training. ambiant air
1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle
Rrs will be measured using the forced oscillation technique (FOT) in cmH₂O·s/L. Values will be assessed before and after the pulmonary rehabilitation cycle at moderate altitude
Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation.
Xrs will be measured using FOT in cmH₂O·s/L. Values will be compared before and after the pulmonary rehabilitation
Change in ∆Xrs (Difference in Reactance) before and after rehabilitation
∆Xrs will be calculated as the difference between inspiratory and expiratory Xrs values, measured in cmH₂O·s/L, before and after rehabilitation.
Change in Rrs, Xrs and ∆Xrs from low to moderate altitude
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Eastern Switzerland University of Applied Sciences
Lead sponsor
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Collaborator
University of Zurich
Collaborator