Sage (Salvia officinalis) has been reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Several studies indicate that sage supplementation can improve cognitive function. However, more research is needed. The purpose of this study is to examine how sage supplementation affects cognitive function and reaction times in middle-aged men and women.
BMI 18.5-34.9 (inclusive) with a goal of being < 30 on average
Subject agrees to maintain their existing dietary patterns throughout the study period.
Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each test day.
Subject is willing and able to comply with the study protocol.
Individuals with a personal history of a psychiatric disorder.
Individuals who are determined to have liver, renal, cardiovascular, or other metabolic disease.
Current or recent (< 4 weeks) use of any dietary supplements (e.g., choline, lecithin, ginseng, ginkgo biloba, ashwagandha, Bacopa Monnieri, Paullina cupana, Rhodiola rosea, L-theanine, omega-3 fats, Prevagen, etc.), or currently prescribed medications (e.g., Adderall, Mydayis, Ritalin, Concerta, Mythylin, Provigil, Namenda), that may affect cognitive function (focus, concentration, memory, reaction time, energy, etc.).
Alcohol consumption (>2 standard alcoholic drinks/day or >10 drinks/week) or drug abuse/dependence (including regular marijuana or THC use).
Parallel
SageXtra
Dietary supplement333 mg/day of SageXtra sage extract powder in two #0 capsules (167 mg/capsule).
Placebo
Dietary supplement333 mg/day of methylcellulose powder in two #0 capsules.
COMputerized Mental Performance ASsessment System (COMPASS) Test Battery
COMPASS consists of seven components including; 1) Immediate and Delayed Word Recall, 2) Delayed Word Recognition, 3) Delayed Picture Recognition, 4) Corsi Blocks Task, 5) Digit Vigilance, 6) Stroop Test and, 7) Choice Reaction Time evaluated via a computer program.
Physical performance
Evaluation of reaction time via a computer program where the subject has to press a key on the keyboard when an area of the computer screen lights up.
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ESM Technologies, LLC
Lead sponsor
Exercise & Sport Nutrition Lab, Texas A&M University
Collaborator
