Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling in Diabetic Patients

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40-75
SponsorAssiut University

About this trial

To evaluate and follow-up left atrial volume, diastolic function by 2D echocardiography and left atrial strain parameters using speckle-tracking echocardiography in patients with type 2 diabetes mellitus (T2DM) before and after treatment with SGLT2 inhibitors

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosed T2DM on antidiabetic medication not including SGLT2 inhibitors.

HbA1c ≤ 7%.

Age 40-75 years.

Sinus rhythm.

Disqualifiers

History of atrial fibrillation or flutter.

Patients treated with SGLT2 inhibitors.

Severe mitral valve regurgitation or stenosis.

Previous myocardial infarction.

Trial population

Adults aged 40-75 years with a diagnosis of T2DM on stable antidiabetic therapy not including SGLT2 inhibitors

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor

    Drug

    evaluate and follow-up left atrial volume, diastolic function by 2D echocardiography and left atrial strain parameters using speckle-tracking echocardiography in patients with type 2 diabetes mellitus (T2DM) after treatment with SGLT2 inhibitors

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

follow-up and evaluation of LA remodeling in patients with type-2 diabetes mellitus ( T2DM) before and after treatment with SGLT2 inhibitors

The study aims evaluation and follow-up of Left Atrial Strain Parameters assessed by Speckle-Tracking Echocardiography (STE) before and after treatment with SGLT2 inhibitors in patients with type-2 diabetes mellitus at Baseline and 6 months follow-up . Left atrial strain will be measured using 2D speckle-tracking echocardiography, including reservoir strain (%), conduit strain (%), and contraction strain (%)

Time frame
6 months follow-up

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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