Effect of Systemic Vitamin D on Dental Implant Osseointegration
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-60
SponsorFuture University in Egypt
About this trial
The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.
Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 20-60 with diagnosed vitamin D deficiency (<20 ng/mL).
Edentulous area in the posterior mandible or maxilla.
No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
Both genders are included
Disqualifiers
Severe systemic diseases that could interfere with healing.
Patients already on vitamin D or calcium supplements.
Smokers or patients with poor oral hygiene practices.
Pregnant females
Trial design
Design model
Parallel
Treatments tested in this trial
Vit D
Drugto address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment
Treatment groups
10 Participants
are divided into 2 treatment groupsGroup A: supplemental groupActive comparator 1 intervention
Group B: Control GroupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Treatment of Dental Implant Osseointegration
Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.
Time frame
3 Months2
marginal bone loss after prosthesis placement
Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.
Time frame
six months after proshtesis placementSecondary outcomes
1
Implant Survival Rate
Implant survival rate will be determined by the presence of the implant at the 6-month follow-up without any clinical or radiographic signs of failure, such as mobility, pain, infection, or significant bone loss. This outcome reflects the short-term success of the dental implant.
Time frame
six months after prosthesis placementSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov