Effect of Vegan Diet on Microbiome and Metabolism

ConditionVegan Diet

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age20-30

SponsorZhujiang Hospital

About this trial

The goal of this interventional study is to investigate how vegan diet affects health in healthy volunteers, Men and women ages 20 - 30 years old. The main questions it aims to answer are:

Change in Microbial community composition and metabolic alterations Changes in plasma metabolic profile. Researchers will compare changes in microbiota and plasma metabolites profile to see the influence of vegan diet in health. In the dietary trial, participants were first assigned to a 2-week omnivorous diet phase, then switched to a 2-week vegetarian diet phase

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

Oral antibiotic use or acute/chronic inflammation within the past 3 months;

Hormone intake within the past 3 months;

Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism;

Smoking or alcohol consumption;

Trial design

Design model

Single group

Treatments tested in this trial

vegan and omnivorous diet
Dietary supplement
Participants underwent a 2-week omnivorous diet intervention, followed by a 2-week vegan diet intervention

Treatment groups

20 Participants

are divided into 1 treatment group

Group A: Effect of vegan diet on microbiome and metabolismExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Gut microbiota composition in twenty participants

16S rDNA sequencing technology was used to identify the structural and functional changes of intestinal microbiota before and after vegan diet.

Time frame

14days，28days

Secondary outcomes

Metabolomic profile of twenty participants in serum and feces

To determine changes of the metabolomic profile in feces and serum after vegan diet

Time frame

14days, 28days

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Zhujiang Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: