The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
Aged 50 to 65 years
Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
Able to provide informed consent
Another medical cause of menopause e.g., history of bilateral oophorectomy
Allergy or intolerance to dairy products (other allergies or intolerances may be excluded if they are not compatible with the study meals and how they are prepared)
Conditions, medications, or recent changes in medications that cause participants to be metabolically unstable (e.g., renal, cardiovascular, thyroid, polycystic ovary syndrome, type-1 and type-2 diabetes)
Gastric bypass/bariatric surgery in the previous 5 years
Pregnancy or nursing in the prior 12 months
Parallel
Skimmed vs Whole Milk Greek Yogurt
Other interventionParticipants will be randomized to receive a standardized diet with either skimmed milk or whole milk Greek yogurt.
Integrated Muscle Protein Synthesis (iMPS)
Integrated muscle protein synthesis expressed as the fractional synthetic rate (%/day).
Glucose Homeostasis
Mean glucose and mean amplitude of glucose excursions (MAGE) as determined from continuous glucose monitors (CGMs) (mg/dL).
Plasma Essential Amino Acids (EAAs)
Postprandial plasma EAA concentrations (µmol/L) in response to skimmed and whole milk Greek yogurt intake.
Cognition: Reaction Time, Alertness, and Selective Attention
Determined from simple and choice reaction (reaction time and alertness) and the Stroop test (selective attention) (milliseconds; ms).
Cognition: Updating
Determined from the 2-back test (discriminatory ot targets; d').
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University of Arkansas
Lead sponsor
National Dairy Council
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
