Effectiveness of Cognitive Training in Older and Younger Adults

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity of Wisconsin, Madison

About this trial

The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Self-reported normal or corrected-to-normal vision

No known neurological impairments

Age within inclusion range (18-30 Years for Younger Adults and 60-85 Years for Older Adults)

Disqualifiers

Physical handicap (motor or perceptual) that would impede training procedures

Concurrent enrollment in other cognitive training studies

Not being proficient enough in English that would prevent following and understanding all instructions and completing all testing sessions (typically, participants would need to have learned English before age 11; there might be some exceptions that will be decided on a case-by-case basis).

Unable to adhere to training schedule

Trial design

Design model

Factorial

Treatments tested in this trial

  • Visual and / or Auditory Cognitive Tasks (1)

    Behavioral

    Seven sessions (\~45-75 minutes) of cognitive tasks in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.

  • Visual and / or Auditory Cognitive Tasks (2)

    Behavioral

    Two sets of 10 sessions (\~20 minutes) of cognitive tasks either at home or in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.

Treatment groups

1,600 Participants
are divided into 2 treatment groups
Group A: Short Testing GroupActive comparator 1 intervention
Group B: Long Testing GroupActive comparator 2 interventions

Trial outcomes

Primary outcomes

1

Change in the difference between the proportion of hits minus false alarms for a given level of the N-back task

The n-Back Task is a measure of working memory. The participant is sequentially shown a series of letters and is asked to indicate whether the current letter matches the letter presented "n" items before. The n levels range between 1- and 4-back. Each level of n-back has 17-19 letters, with 5 target letters.

Time frame
Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days
2

Change in the proportion of correctly reported sequences in the Corsi Complex task

The Corsi Complex Task is a measure of working memory. The participant is sequentially shown a series of positions from 12 possible predefined spots on the screen. Between each position, the participants is also asked to categorize a stimulus between two categories based on color and shape. The participant's task is to report the sequence of positions in order. The length of sequence can vary between 2 and 10.

Time frame
Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days
3

Change in the proportion of correctly reported number and letter sets in the Letter-Number task

The Letter-Number Sequence Task is a measure of working memory. In each trial, the participant is presented with a sequence of alternating letters and numbers, from 2 to 10 stimuli. Participants have to report the numbers in ascending order, and the letters in alphabetical order.

Time frame
Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days
4

Change in the difference of response time and accuracy in switch trials minus non-switch trials in the Task Switching Task

The Task Switching task is a measure of cognitive flexibility. On each trial, participants view a letter and a digit. A cue tells the participant to either categorize the letter as a consonant or vowel or else categorize the digit as even or odd. Trials can be either "non-switch trials" - in which the participant is asked to perform the same task as on the previous trial - or "switch trials" - in which the participant is asked to perform the opposite task as on the previous trial. The participant will complete 48 trials. A "switch cost" is calculated by subtracting the average response time for switch trials from the average response time for non-switch trials.

Time frame
Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days

Secondary outcomes

1

Big-5-Inventory 10-item version (BFI-10) Score

Individual differences in personality moderating the potential link between expectations and performance on the battery of cognitive tasks. BFI-10 measures the individuals' personality traits: conscientiousness, agreeableness, neuroticism, openness to experience, and extraversion. The total possible range of scores is from 1-5 for each personality traits, where higher scores indicate higher expression of this personality trait.

Time frame
Pre-Test
2

Behavioral Inhibition/Activation System (BIS/BAS) Score

Individual differences in reward sensitiveness moderating the potential link between expectations and performance on the battery of cognitive tasks. BIS/BAS measures the sensitivity to reward through four components, one inhibition component (punishment sensitivity) and three activation components (fun seeking, reward responsiveness, and drive). The total possible range of scores is from 1-4, where higher scores indicate higher expression of each dimension of the questionnaire.

Time frame
Pre-Test
3

Grit and Conscientiousness Score

Individual differences in grit and conscientiousness moderating the potential link between expectations and performance on the battery of cognitive tasks. Grit and Consciousness measures the tendency to sustain effort toward long-term goals. The total possible range of scores is from 1-5, where higher scores indicate higher levels of grit and conscientiousness.

Time frame
Pre-Test
4

Meta-Cognition Score

Individual differences in meta-cognitive skills moderating the potential link between expectations and performance on the battery of cognitive tasks. Meta-Cognition measures the ability to understand one's own abilities, strengths, and weaknesses. The total possible range of scores is from 1-5, where higher scores indicate higher meta-cognitive skills.

Time frame
Pre-Test

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Wisconsin, Madison

Lead sponsor

National Institute on Aging (NIA)

Collaborator