About this trial
The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Self-reported normal or corrected-to-normal vision
No known neurological impairments
Age within inclusion range (18-30 Years for Younger Adults and 60-85 Years for Older Adults)
Disqualifiers
Physical handicap (motor or perceptual) that would impede training procedures
Concurrent enrollment in other cognitive training studies
Not being proficient enough in English that would prevent following and understanding all instructions and completing all testing sessions (typically, participants would need to have learned English before age 11; there might be some exceptions that will be decided on a case-by-case basis).
Unable to adhere to training schedule
Trial design
Factorial
Treatments tested in this trial
Visual and / or Auditory Cognitive Tasks (1)
BehavioralSeven sessions (\~45-75 minutes) of cognitive tasks in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.
Visual and / or Auditory Cognitive Tasks (2)
BehavioralTwo sets of 10 sessions (\~20 minutes) of cognitive tasks either at home or in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.
Treatment groups
Trial outcomes
Primary outcomes
Change in the difference between the proportion of hits minus false alarms for a given level of the N-back task
The n-Back Task is a measure of working memory. The participant is sequentially shown a series of letters and is asked to indicate whether the current letter matches the letter presented "n" items before. The n levels range between 1- and 4-back. Each level of n-back has 17-19 letters, with 5 target letters.
Change in the proportion of correctly reported sequences in the Corsi Complex task
The Corsi Complex Task is a measure of working memory. The participant is sequentially shown a series of positions from 12 possible predefined spots on the screen. Between each position, the participants is also asked to categorize a stimulus between two categories based on color and shape. The participant's task is to report the sequence of positions in order. The length of sequence can vary between 2 and 10.
Change in the proportion of correctly reported number and letter sets in the Letter-Number task
The Letter-Number Sequence Task is a measure of working memory. In each trial, the participant is presented with a sequence of alternating letters and numbers, from 2 to 10 stimuli. Participants have to report the numbers in ascending order, and the letters in alphabetical order.
Change in the difference of response time and accuracy in switch trials minus non-switch trials in the Task Switching Task
The Task Switching task is a measure of cognitive flexibility. On each trial, participants view a letter and a digit. A cue tells the participant to either categorize the letter as a consonant or vowel or else categorize the digit as even or odd. Trials can be either "non-switch trials" - in which the participant is asked to perform the same task as on the previous trial - or "switch trials" - in which the participant is asked to perform the opposite task as on the previous trial. The participant will complete 48 trials. A "switch cost" is calculated by subtracting the average response time for switch trials from the average response time for non-switch trials.
Secondary outcomes
Big-5-Inventory 10-item version (BFI-10) Score
Individual differences in personality moderating the potential link between expectations and performance on the battery of cognitive tasks. BFI-10 measures the individuals' personality traits: conscientiousness, agreeableness, neuroticism, openness to experience, and extraversion. The total possible range of scores is from 1-5 for each personality traits, where higher scores indicate higher expression of this personality trait.
Behavioral Inhibition/Activation System (BIS/BAS) Score
Individual differences in reward sensitiveness moderating the potential link between expectations and performance on the battery of cognitive tasks. BIS/BAS measures the sensitivity to reward through four components, one inhibition component (punishment sensitivity) and three activation components (fun seeking, reward responsiveness, and drive). The total possible range of scores is from 1-4, where higher scores indicate higher expression of each dimension of the questionnaire.
Grit and Conscientiousness Score
Individual differences in grit and conscientiousness moderating the potential link between expectations and performance on the battery of cognitive tasks. Grit and Consciousness measures the tendency to sustain effort toward long-term goals. The total possible range of scores is from 1-5, where higher scores indicate higher levels of grit and conscientiousness.
Meta-Cognition Score
Individual differences in meta-cognitive skills moderating the potential link between expectations and performance on the battery of cognitive tasks. Meta-Cognition measures the ability to understand one's own abilities, strengths, and weaknesses. The total possible range of scores is from 1-5, where higher scores indicate higher meta-cognitive skills.
Sponsors and contacts
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University of Wisconsin, Madison
Lead sponsor
National Institute on Aging (NIA)
Collaborator