Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssiut University

About this trial

Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing. Malignant pleural effusion (MPE) is an exudative effusion with malignant cells.

It is a common symptom and accompanying presentation of metastatic disease. It Impacts up to 15% of all patients with cancer and is the most common in breast, lung, cancer, lymphoma, and gynaecological malignancies . There are 150,000 new cases of MPE in the United States yearly and 100,000 in Europe . Patients have an overall survival (OS) rate of 3-12 months after the initial diagnosis . Malignant pleural effusion (MPE) poses significant challenges in management, impacting patient quality of life and overall prognosis. Almost all radiological procedures can help diagnose pleural effusions . Thoracentesis is used as a diagnostic and therapeutic tool. The procedure has been modified with the addition of ultrasound, that is very functional for targeting certain anatomical areas of the pleura and finding an appropriate entry point . Three primary strategies are commonly employed: intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration. This study aims to evaluate these methods' efficacy, safety, and outcomes. To compare intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patient aged 18 years old and above.

Patients diagnosed with massive malignant pleural effusion (MPE) requiring intervention.

Disqualifiers

Pediatric patients aged below 18 years

Patients with non-malignant causes of pleural effusion.

Trial design

Design model

Parallel

Treatments tested in this trial

  • intercostal tube drainage

    Procedure/Surgery

    intercostal tube drainage in managing massive malignant pleural effusion (MPE).

  • big tail catheter drainage

    Procedure/Surgery

    big tail catheter drainage in managing massive malignant pleural effusion (MPE).

  • ultrasound-guided aspiration

    Procedure/Surgery

    ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).

Treatment groups

66 Participants
are divided into 3 treatment groups
Group A: Group AActive comparator 1 intervention
Group B: Group BActive comparator 1 intervention
Group C: Group CActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Resolution of Pleural Effusion

Resolution of Pleural Effusion: Defined as complete or partial resolution based on imaging studies (e.g., chest X-ray or ultrasound).

Time frame
baseline

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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