About this trial
Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing. Malignant pleural effusion (MPE) is an exudative effusion with malignant cells.
It is a common symptom and accompanying presentation of metastatic disease. It Impacts up to 15% of all patients with cancer and is the most common in breast, lung, cancer, lymphoma, and gynaecological malignancies . There are 150,000 new cases of MPE in the United States yearly and 100,000 in Europe . Patients have an overall survival (OS) rate of 3-12 months after the initial diagnosis . Malignant pleural effusion (MPE) poses significant challenges in management, impacting patient quality of life and overall prognosis. Almost all radiological procedures can help diagnose pleural effusions . Thoracentesis is used as a diagnostic and therapeutic tool. The procedure has been modified with the addition of ultrasound, that is very functional for targeting certain anatomical areas of the pleura and finding an appropriate entry point . Three primary strategies are commonly employed: intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration. This study aims to evaluate these methods' efficacy, safety, and outcomes. To compare intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patient aged 18 years old and above.
Patients diagnosed with massive malignant pleural effusion (MPE) requiring intervention.
Disqualifiers
Pediatric patients aged below 18 years
Patients with non-malignant causes of pleural effusion.
Trial design
Parallel
Treatments tested in this trial
intercostal tube drainage
Procedure/Surgeryintercostal tube drainage in managing massive malignant pleural effusion (MPE).
big tail catheter drainage
Procedure/Surgerybig tail catheter drainage in managing massive malignant pleural effusion (MPE).
ultrasound-guided aspiration
Procedure/Surgeryultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).
Treatment groups
Trial outcomes
Primary outcomes
Resolution of Pleural Effusion
Resolution of Pleural Effusion: Defined as complete or partial resolution based on imaging studies (e.g., chest X-ray or ultrasound).
Locations
Sponsors and contacts
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This trial is not recruiting at the moment. You can still explore other options: