About this trial
The aims of this study is to evaluate the effectiveness of non-pharmacological interventions program in preventing progression from mild cognitive impairment to dementia in patients with mild cognitive impairment in the short term, at Nhân dân Gia Định Hospital, Hồ Chí Minh City.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Cognitive complaints from the subject or a family member.
Report a decline in cognitive function compared to the subject's previous ability over the past year OR
Evidence from clinical assessment, specifically here is MMSE screening with results of 24-29 points.
Subjects did not suffer major impacts from cognitive complaints on daily life.
Disqualifiers
Don't know Vietnamese writing.
Audio-visual ability does not meet the requirements of assessment tests and prevention programs.
Systemic diseases are contraindications/ restriction to participation in programs and/or cause secondary cognitive impairment (traumatic brain injury, stroke, brain tumor, parkinsonism, epilepsy, acute coronary artery disease, acute myocardial infarction, bone fractures...).
The assessment score on the Geriatric Depression Scale (GDS-15) is ≥ 5 points.
Trial design
Parallel
Treatments tested in this trial
Home-based cognitive training exercises
Other interventionThe subjects received (i) education on lifestyle modification, (ii) home-based cognitive training exercises with physiotherapist/ physiatrist contact when needed and (iii) a physical training exercises conducted at hospital under the supervision of physiotherapist/ physiatrist (3 weekly session for 12 weeks). This arm has a duration of 12 weeks.
Supervised cognitive training exercises
Other interventionThe subjects received (i) education on lifestyle modification, (ii) supervised cognitive training exercises at hospital (1 weekly session for 12 weeks) and (iii) a physical training exercises conducted in a hospital under the supervision of physiotherapist/ physiatrist (3 weekly session for 12 weeks). This arm has a duration of 12 weeks.
Treatment groups
Trial outcomes
Primary outcomes
Effectiveness of Intervention Program
Evaluating the effectiveness of preventing progression from mild cognitive impairment to dementia using the Montreal Cognitive Assessment (The MoCA Test) in patients with mild cognitive impairment in the short term. Higher scores mean a better outcome. The following result ranges may indicate cognitive impairment: 18-25 points: Mild cognitive impairment. 10-17 points: Moderate cognitive impairment. Fewer than 10 points: Severe cognitive impairment.
Secondary outcomes
Change in Activities of Daily Living
Evaluating improvement using The Lawton Instrumental Activities of Daily Living Scale (IADL). Higher scores mean a better outcome.
Change in physical fitness
Evaluating improvement using The Senior Fitness Test Kit (Chair stand test, Arm curl test, Step in place test, Up and go test). Higher scores mean a better outcome (except Up and go test).
Change in mental health
Evaluating improvement using Geriatric Depression Scale-15 (GDS15). Higher scores mean a worse outcome.
Patient Adherance
Adherence is assessed considering the number of individuals who have accepted to participate in the study relative to the number of participants who are recruited. Low \< 80%, moderate 80-90%, high \> 90%
Sponsors and contacts
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