Health TrialsbyHealthPanel

Effects and Mechanisms of Dietary Carbohydrate Intake and Quality on Glucose and Lipid Metabolism

ConditionsMetabolic Syndrome (MetS)Metabolic Syndrome Risk Factors
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorSun Yat-sen University

About this trial

This study aimed to explore the effects of quantity and quality of dietary carbohydrate intakes on glucose and lipid levels and metabolism, as well as gut microbiota by a randomized crossover controlled intervention trial.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male and female aged 18 - 65 years;

BMI 20 - 35 kg/m2;

Consent to be randomly assigned to an intervention or control group;

Willingness to eat the food and beverages provided in the study;

Disqualifiers

Use of medications that affect blood glucose metabolism;

Familial hyperlipidemia, or use of drugs that affect lipid metabolism;

Long-term or current use of nonsteroidal anti-inflammatory drugs, antibiotics, antihistamines, or immunomodulatory drugs, and unable to stop taking these drugs within 72 h before the start of the study;

Use of hormonal medications such as anticoagulants, anabolic steroids, and hydrocortisone;

Trial design

Design model

Crossover

Treatments tested in this trial

  • Diet

    Other intervention

    Diet with high carbohydrate contents and high GI values.

  • Diet

    Other intervention

    Diet with high carbohydrate contents and low GI values.

  • Diet

    Other intervention

    Diet with low carbohydrate contents and high GI values.

  • Diet

    Other intervention

    Diet with low carbohydrate contents and low GI values.

Treatment groups

20 Participants
are divided into 4 treatment groups
Group A: High-carbohydrate high-GI dietOther 1 intervention
Group B: High-carbohydrate low-GI dietOther 1 intervention
Group C: Low-carbohydrate high-GI dietOther 1 intervention
Group D: Low-carbohydrate low-GI dietOther 1 intervention

Trial outcomes

Primary outcomes

1

Glucose

Time frame
22-week period
2

Lipids

Time frame
22-week period

Secondary outcomes

1

Insulin

Time frame
22-week period
2

LDL and HDL subfractions

Time frame
22-week period
3

Gut microbiota

Time frame
22-week period
4

Bile acid

Time frame
22-week period

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sun Yat-sen University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: