Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age25-50
SponsorPeking University Third Hospital
About this trial
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
(1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg/m²; (4) good general health status.
Disqualifiers
(1) history of alcoholism; (2) smoking ≥5 cigarettes/day in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.
Trial design
Design model
Single group
Treatments tested in this trial
60-day-6° head-down bed rest
BehavioralThroughout the bed rest period, subjects carried out all activities of daily living-eating, voiding, recreation, and testing
Treatment groups
26 Participants
are divided into 1 treatment groupGroup A: Long term bed rest intervention groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
T2 mapping
metabolic and microstructural changes within the articular cartilage matrix components can be assessed, reflecting collagen fiber structure integrity and water content within the tissue
Time frame
three days before the HDBR started and three days after the HDBR endedSecondary outcomes
1
Y-balance test
can comprehensively evaluate an individual's joint range of motion, lower limb strength, sense of balance, and neuromuscular control, as well as the postural control and dynamic stability of lower limbs.
Time frame
three days before the HDBR started and three days after the HDBR ended2
International Knee Documentation Committee (IKDC) scores
reflects the highest level of activity that an individual is able to perform.
Time frame
three days before the HDBR started and three days after the HDBR endedSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov