About this trial
Curcumin (a bioactive compound found in turmeric) has demonstrated anti-inflammatory and antioxidant properties, and there is evidence to suggest that it may produce improvements in quality of life and markers of health in humans with various conditions. To date, the research has often focussed on the effects of curcumin in human participants with a particular condition. However, turmeric contains hundreds of other bioactive compounds (including other curcuminoids and essential oils) and may be able to benefit a wide range of older adults. Therefore, the aim of this study is to investigate the effects of twice daily consumption of a turmeric beverage for 8-weeks on the physiology and wellbeing of older adults (versus placebo).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
History of, or currently diagnosed with, a cardiovascular disease.
Diagnosed with diabetes.
Diagnosed with a liver, lung, or kidney disease.
Diagnosed with osteoporosis.
Trial design
Parallel
Treatments tested in this trial
Raw turmeric shots
Dietary supplementThis group will take one 60 mL commercially-available shot (containing 30% turmeric) twice per day for 8 weeks.
Placebo
Other interventionThis group will take one placebo shot (containing a small amount of turmeric for taste-matching purposes) twice per day for 8 weeks.
Treatment groups
Trial outcomes
Primary outcomes
Plasma/serum Brain-derived neurotrophic factor
Measured using ELISA. We will analyse raw and percentage change values.
Plasma/serum total cholesterol
Measured using pentra C400 clinical chemistry analyser, We will analyse raw and percentage change values.
Chalder Fatigue Scale (CFS)
This questionnaire measures participants' severity of physical and mental fatigue. This will be scored "Likert style" from 0-33. Higher scores indicate greater levels of fatigue.
Secondary outcomes
Plasma/serum creatinine
Measured using pentra C400 clinical chemistry analyser, We will analyse raw and percentage change values.
Depression Anxiety Stress Scales - 21 items (DASS-21)
Participants choose from a range of questions designed to measure the severity of a range of symptoms common to both depression and anxiety. Scoring is based on a likert scale where higher scores relate to increased severity of depression, anxiety and stress.
McGill Pain Questionnaire
This questionnaire is used to evaluate a person experiencing significant pain. It can be used to monitor pain over time. Someone experiencing no pain would score 0 while the maximum score for pain would be 78.
36-Item Short Form Survey (SF-36)
This survey consists of generic questions covering eight health domains: physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to personal or emotional problems, emotional well-being, social functioning, energy/fatigue, and general health perceptions. To score the survey, firstly, responses to items relate to scores between 0-100. Secondly, using a table, items in the same scale are averaged together to create the eight domains.
Sponsors and contacts
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Nottingham Trent University
Lead sponsor
Innate-Essence Limited
Collaborator