Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age15-39
SponsorThe Hong Kong Polytechnic University
About this trial
Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years. Large language models (LLMs) offer a promising solution to bridge onco-fertility service gaps by integrating evidence-based knowledge and therapeutic frameworks. This pilot randomized controlled trial aims to assess the feasibility and preliminary effectiveness of an LLM-driven chatbot versus electronic brochure in addressing reproductive concerns among AYA cancer survivors.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial design
Design model
Parallel
Treatments tested in this trial
Chatbot
Other interventionA large language model-driven chatbot that incorporates acceptance and commitment therapy, a verified onco-fertility knowledge base, and relevant policy information.
Electronic brochure
Other interventionAn electronic brochure that contains psychoeducational materials, verified onco-fertility knowledge, and relevant policy information.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: ChatbotExperimental treatment 1 intervention
Group B: Electronic brochureActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Total interaction time
The cumulative time spent interacting with the chatbot or reading the electronic brochure during the study period.
Time frame
At 4 weeks, 8 weeks2
Number of active days
The total number of distinct days on which a participant actively engaged with the chatbot or accessed the electronic brochure.
Time frame
At 4 weeks, 8 weeks3
Dropout rate
The proportion of randomized participants who do not complete the intervention or outcome measures.
Time frame
At 4 weeks, 8 weeksSecondary outcomes
1
Reproductive concerns
Measured by Reproductive Concerns After Cancer (RCAC) scale.
Time frame
At baseline, 4 weeks, 8 weeks2
Psychological flexibility
Measured by The second version of the Acceptance and Action Questionnaire (AAQ-II).
Time frame
At baseline, 4 weeks, 8 weeks3
Depression
Measured by Patient Health Questionnaire-9 (PHQ-9).
Time frame
At baseline, 4 weeks, 8 weeks4
Life quality
Measured by World Health Organization Quality of Life-BREF (WHOQOL-BREF).
Time frame
At baseline, 4 weeks, 8 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
The Hong Kong Polytechnic University
Lead sponsor
The University of Science and Technology of China
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: