About this trial
This study will compare the effects of a whey protein supplement or a placebo consumed before the evening meal on health outcomes in night shift workers.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Female
Night shift workers (with a minimum of 6 months in their current shift work schedule)
35-65 years
BMI 28.0-35.0 kg/m2; waist circumference > 80cm
Disqualifiers
Those working standard day time hours only, or those who work less than three to four night shifts per fortnight on average
Personal history and/or diagnosis of: diabetes, cancer, major psychiatric disorders, liver disease, gastro-intestinal surgery or disease (including malabsorption), eating disorders, anaemia, insomnia or cardiovascular disease, and/or any other condition deemed unstable by the study physician
Taking medications known to alter body composition or metabolism, including (but not limited to): any medication used to lower blood glucose or antidiabetic medications (metformin, sulfonylureas, Glucagon-like peptide-1 (GLP-1) analogues [i.e. exenatide], thiazolidinediones or DPP-IV inhibitors [i.e. 'gliptins']), medications affecting weight, appetite or gut motility (i.e. diuretics, domperidone, cisapride, orlistat, phentermine, topiramate)
Participants who are taking stable doses (i.e. > 12 months) of androgenic medications (i.e. testosterone) or SSRI's will not be excluded. Personal history/diagnosis (self-reported) of diabetes (type 1 or 2), major psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, eating disorders), gastrointestinal disorders, haematological disorders (i.e. thalassemia, iron-deficiency anaemia) insomnia, or any other medical condition, deemed unstable by the study physician
Trial design
Crossover
Treatments tested in this trial
whey protein
Dietary supplementProtein drink containing 30g whey protein isolate powder (dissolved in water) consumed 1-1.5 hr prior to their main evening meal every day for 12 days, No other advice will be given.
Placebo
Dietary supplementEnergy-matched mixed-nutrient placebo drink consumed 1-1.5 hr prior to their main evening meal every day for 12 days. No other advice will be given.
Treatment groups
Trial outcomes
Primary outcomes
Glycaemic response
Change in glucose (AUC) following a standard breakfast
Secondary outcomes
24-hour glucose profiles
Change in 24-hour glucose profiles assessed by continuous glucose monitoring
Glucose variability
Change in 24-hour glucose variability (as SD, standard deviation) assessed by continuous glucose monitoring
Glucose variability
Change in 24-hour glucose variability (as CV, coefficients of variation) assessed by continuous glucose monitoring
Glucose variability
Change in 24-hour glucose variability (as MAGE, mean amplitude of gylcaemic excursions) assessed by continuous glucose monitoring
Sponsors and contacts
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