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Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women

ConditionsHypertensionHypertension (HTN)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age60+
SponsorSão Paulo State University

About this trial

The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure. The main questions it aims to answer are:

Does beetroot extract affect blood pressure during exercise? Does it change oxygen levels in the muscles? Participants will take a beetroot supplement and perform an aerobic exercise session to check how their bodies respond.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Female sex: Older women aged between 60 and 70 years.

Physical capability: Absence of health conditions that could compromise performance in the required physical exercise tests.

Disqualifiers

Smoking: Current smokers.

Alcohol use: History of alcohol abuse or excessive alcohol consumption.

Cardiovascular Disease: Diagnosis of cardiovascular diseases (other than the primary condition of hypertension).

Trial design

Design model

Single group

Treatments tested in this trial

  • Beetroot Extract (Nitrate-rich)

    Dietary supplement

    Participants will ingest 2 capsules of a standardized beetroot extract (Berkeley Life Nitric Oxide Foundation). Each dose provides approximately 314 mg of dietary nitrate.

  • Placebo

    Dietary supplement

    Capsules identical in appearance, color, and size to the experimental supplement, but containing an inert substance (starch). This intervention is used to maintain the double-blind design of the study.

  • Exercise

    Behavioral

    Participants will perform a single aerobic exercise session on a treadmill. The protocol consists of a 7-minute warm-up followed by 30 minutes of continuous exercise at an intensity corresponding to 60-80% of maximum heart rate (HRmax), estimated using Tanaka's formula (208 - 0.7 \* age). Rate of Perceived Exertion (RPE) will be monitored periodically using the Borg scale (6-20).

  • Rest (Control Condition)

    Other intervention

    Participants will remain seated for 30 minutes (matching the exercise session duration). During this time, a researcher will administer a Food Frequency Questionnaire (FFQ) in an interview format. This activity serves to assess dietary habits and simulates a routine, low-exertion daily activity (similar to a conversation), acting as a time-matched control for the exercise session.

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: Experimental Group (All Participants)Experimental treatment 4 interventions

Trial outcomes

Primary outcomes

1

Systolic and Diastolic Blood Pressure

Assessed using a validated automatic or semi-automatic device. Results measured in millimeters of mercury (mmHg).

Time frame
Baseline (Rest), during intervention (at 10 and 20 minutes), immediately post-intervention (at 30 minutes), and 10 minutes post-intervention recovery.

Secondary outcomes

1

Muscle Oxygen Saturation

Assessed via Near-Infrared Spectroscopy (NIRS) placed on the vastus lateralis muscle. Measured in percentage (%).

Time frame
Continuously recorded during the 30-minute exercise session.
2

Oxidative Stress Markers (SOD, CAT, GPx, MDA)

Analysis of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), and Malondialdehyde (MDA) levels in blood plasma. Results measured in nanomoles per minute per gram of protein (nmol/min/g).

Time frame
Baseline (Pre-intervention) and immediately post-intervention (after exercise or rest).

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

São Paulo State University

Lead sponsor

Universidade Estadual Paulista Júlio de Mesquita Filho

Sponsor institution

Source ClinicalTrials.gov
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