Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH surgery. If manipulating nighttime light in hospital rooms improves patient outcomes, then it would be a relatively easy and inexpensive innovation that could reduce post-surgical complications and save millions of dollars per year in health care costs by shortening the length of hospital stays and reducing morbidity. The investigators aim to determine the relationship between inflammation and cognitive dysfunction after cardiac surgery.
Both men and women that are undergoing elective (non-emergency)
on-pump CABG surgery,
AVR,
MVR,
Evidence or diagnosis of dementia or other cognitive deficit
Diagnosed psychiatric disorder (including depression and anxiety)
Organ failure [kidney (creatine > 1.5 mg/dL), liver, etc.]
Chronic obstructive pulmonary disease,
Parallel
Blue light-blocking goggles
Other interventionParticipants will be randomly assigned to one of the two intervention groups.
Clear goggles
Other interventionParticipants will be randomly assigned to one of the two intervention groups.
Change in baseline serum cytokine profile
Assessed via an immuno multiplex panel for the following cytokines:TNF-α, IL-1β, IL-6, IL-2, and IL-8. Units of measure for all cytokines are pg/mL.
Change in baseline serum cytokine profile
Assessed via an immuno multiplex panel for the following cytokines:TNF-α, IL-1β, IL-6, IL-2, and IL-8. Units of measure for all cytokines are pg/mL.
Change in baseline serum cardiac ischemia profile
Assessed via an immuno multiplex panel for the following indicators of ischemia: CRP, BNP, NT-proBNP, cardiac troponin T, and CK-MB. Units of measure for all indicators of ischemia are pg/mL.
Change in baseline serum cardiac ischemia profile
Assessed via an immuno multiplex panel for the following indicators of ischemia: CRP, BNP, NT-proBNP, cardiac troponin T, and CK-MB. Units of measure for all indicators of ischemia are pg/mL.
Click on the lead sponsor to view all of their trials.
