The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.
30 to 75 years of age
Among patients with hypertension, no change in BP medication for at least 3 months.
Willing and able to give informed consent
Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6-months.
Unable to apply BP cuff (e.g. arm circumference >55 cm, prior breast cancer, structural abnormalities of the arm)
Current use of CPAP or Dental Device for OSA
Category III-IV of heart failure
Presence of Cheyne-Stokes Respiration (CSR) in PSG
Adults between the ages of 30 to 75 years old with moderate to severe obstructive sleep apnea (OSA). OSA diagnosis will be defined as an apnea/hypopnea index (AHI) \>or =5 episodes per hour.
Cohort
Prospective
CPAP therapy
DeviceCPAP treatment of obstructive sleep apnea.
24-hour Mean Blood Pressure
24-hour Mean Blood Pressure obtained from ambulatory blood pressure monitoring (ABPM)
Heart Rate Variability
Heart Rate Variability obtained from 5-minute ECG
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Ohio State University
Lead sponsor
University of Pennsylvania
Collaborator
Chang Gung Memorial Hospital
Collaborator
University of Sydney
Collaborator
The University of Western Australia
Collaborator
Peking University
Collaborator
Ruijin Hospital
Collaborator
National University of Singapore
Collaborator
University of Iceland
Collaborator
Geisinger Health
Collaborator
Charite University, Berlin, Germany
Collaborator
