Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-70
SponsorUniversity of California, Davis
About this trial
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a healthy meal, will promote the absorption of zinc into cells, where the zinc will have greater effects on zinc-dependent metabolic processes supporting cardiovascular health. To maximize the observability of these beef-related effects, individuals who are 55- to 70-year-old who generally have a higher risk of zinc deficiency and cardiovascular disease will be enrolled.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or postmenopausal female 55-70 years of age
Women: lack of menses for at least two years.
Subject is willing and able to comply with the study protocols.
Subject is willing to participate in all study procedures
Disqualifiers
Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
Prescribed metaformin, statins or medications known to interfere with zinc, protein, or lipid metabolism
Vegan, Vegetarians, food faddists or those consuming a non-traditional diet (e.g. Adkins, Keto, Paleo, etc.)
Fruit consumption ≥ 3 cups/day
Trial design
Design model
Crossover
Treatments tested in this trial
Beef protein
Other interventionAnimal protein source
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: Beef ProteinExperimental treatment 1 intervention
Group B: Animal ProteinActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
microvascular function
microvascular function as measured by digital tonometry (EndoPAT2000)
Time frame
4 weeks2
intracellular zinc status
intracellular zinc status determined by erythrocyte zinc tracer exchange
Time frame
4 weeksSecondary outcomes
1
plasma lipids
Circulating level of total cholesterol, triglycerides, HDL cholesterol, non-HDL cholesterol, with LDL cholesterol (calculated)
Time frame
4 weeks2
plasma fatty acids
Circulating levels of non-esterified fatty acids
Time frame
4 weeks3
plasma oxylipins
enzyme and non-enzyme derived non-esterified fatty acid metabolites
Time frame
4 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of California, Davis
Lead sponsor
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Collaborator
Source ClinicalTrials.gov