Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors. The majority of colorectal cancer cases (approximately 85%) are not caused by hereditary mutations. Environmental factors, such as lifestyle or diet (notably through endocrine disruptors), can affect the gut microbiota (a collection of microorganisms - bacteria, viruses, parasites, and fungi - residing in the intestinal environment) and lead to disturbances in its composition, referred to as dysbiosis. While the mechanisms underlying dysbiosis associated with colorectal cancer remain poorly understood, the involvement of certain ingested substances, known as xenobiotics, is increasingly suspected, including endocrine disruptors. Among the most common endocrine disruptors found in water and food are parabens and phthalates, which will be examined in detail in this study. These substances may be directly involved in the development of colorectal cancer and in response to its treatment.
The main objective of this studie is to characterize the relationship between colorectal cancer diagnosis, activity/composition of the gut microbiota, and patients' exposure to selected endocrine disruptors, particularly parabens and phthalates.
Scheduled endoscopy during the inclusion visit or within 18 months following this consultation.
Signed consent from the patient after clear and fair information about the study is provided.
Patient is free of guardianship, curatorship, or dependency.
Patient is covered by a social security system or through a third party.
Patients receiving treatment for chronic inflammatory bowel disease;
Patients with hereditary colorectal cancer;
Use of antibiotics, probiotics, or prebiotics within four weeks prior to stool sample collection;
Patients who have undergone neoadjuvant chemotherapy or radiotherapy;
Parallel
Collection of biological samples and clinical data
Other intervention* Collection of a hair sample * Collection of urine * Collection of stool samples * Collection of clinical, paraclinical data, and exposure questionnaire
Association between faecal microbiota disruption and exposure to endocrine disruptors
Association between disruptions in the composition and/or activity of the faecal microbiota (sequencing and metabolome analysis) and exposure to endocrine disruptors (measured in urine and stool samples) in patients with colorectal cancer and in controls
Describe the accumulated exposome
LC/MS on hair samples
Describe gut microbiota composition
From stool samples
Detect differences in pro-carcinogenic bacteria
In stool samples
Correlation metabolome / gut microbiota in patients with colorectal cancer
Analysis of the correlation between the metabolome and gut microbiota in colorectal cancer patients
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Poitiers University Hospital
Lead sponsor
University of Poitiers - Laboratoire Ecologie et Biologie des Interactions (EBI) - UMR CNRS 7267
Collaborator
