Effects of Endogenous Gamma Light Stimulation on Brain Oscillations in Cognitively-normal Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55+
SponsorChang Gung Memorial Hospital
About this trial
This study aims to evaluate the effects of endogenous gamma non-flickering light stimulation on resting-state EEG rhythms and cognitive function in cognitively healthy older adults. Specifically, it will assess the immediate and long-term effects of this stimulation on brainwave activity and cognitive performance. The study will explore the potential of gamma light stimulation as a non-pharmacological intervention for cognitive decline in aging populations.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
1. Age over 55 years old.
2. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.
3. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.
4. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).
Disqualifiers
1. Participants enrolled in any cognitive enhancement study within the past two months.
2. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).
3. Pregnant, or planning to become pregnant.
Trial design
Design model
Parallel
Treatments tested in this trial
Gamma Wave Stimulation Table Lamp (Aleddra, Inc., USA)
DeviceParticipants will receive light stimulation using the Gamma Wave Stimulation Table Lamp (Aleddra, Inc., USA) for 1 hour per day, 7 days a week, over 4 weeks, for a total of 28 hours.
Treatment groups
52 Participants
are divided into 2 treatment groupsGroup A: endogenous gamma lightActive comparator 1 intervention
Group B: Sham (70Hz) gamma lightSham comparator 1 intervention
Trial outcomes
Primary outcomes
1
Changes in gamma brain oscillations.
Gamma (31-100Hz) brain oscillations obtained through resting-state EEG will evaluate the changes of gamma light stimulation intervention.
Time frame
baseline (T1), post one-hour intervention (T2), post one-month intervention (T3)Secondary outcomes
1
Change score of the Cognitive Abilities Screening Instrument (CASI).
CASI will be applied to measure the participant's general cognitive ability. The range of score is 0 to 100, with a higher score indicating better performance.
Time frame
baseline (T1), post one-month intervention (T3)2
Change score of the Chinese version Verbal Learning Test (CVVLT).
A nine-item of CVVLT (total recall, delayed recall) will be applied to measure the participant's memory ability, with a higher score indicating better performance.
Time frame
baseline (T1), post one-month intervention (T3)3
Change score of the WMS-III logical memory test
WMS-III logical memory test (immediate recall, delayed recall) will be applied to measure the participant's memory ability. The maximum score is 25 for each recall trial, with a higher score indicating better performance
Time frame
baseline (T1), post one-month intervention (T3)4
Change score of the Taylor Complex Figure Test (TCFT).
TCFT (immediate recall, delayed recall) will be applied to measure the participant's memory ability. The maximum score is 36 for each recall trial, with a higher score indicating better performance.
Time frame
baseline (T1), post one-month intervention (T3)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Chang Gung Memorial Hospital
Lead sponsor
Aleddra, Inc.
Collaborator
Source ClinicalTrials.gov