Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals

ConditionBloodpressure

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-40

SponsorUniversity Hospital, Gentofte, Copenhagen

About this trial

The present study investigates the postprandial role of endogenous glucose-dependent insulinotropic polypeptide (GIP) on cardiovascular haemodynamics, hormone responses, and hypotensive symptoms during a tilt test.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 18-40 years

BMI between 18.5 and 29.9 kg/m2 (both included)

Informed consent

Disqualifiers

Allergy or intolerance to ingredients included in the mixed meal

History of Orthostatic Hypotension (OH) or Postural Orthostatic Tachycardia Syndrome (POTS) or other autonomic dysfunction at the discretion of the investigators

Anaemia (haemoglobin below normal range <7.3 mmol/L for women and <8.3 mmol/L for men)

Kidney disease (estimated glomerular filtration rate (eGFR) <90 ml/min/1.73 m2) at screening

Trial design

Design model

Crossover

Treatments tested in this trial

GIP(3-30)NH2 / study tool
Other intervention
Selective antagonist of the GIPR, GIP(3-30)NH2
Saline (NaCl 0,9 %) (placebo)
Other intervention
Placebo (NaCl 0,9%)
GIP(1-42)
Other intervention
Agonist of the GIPR, GIP(1-42)

Treatment groups

16 Participants

are divided into 4 treatment groups

Group A: GIP(3-30)NH2 + mixed meal testExperimental treatment 2 interventions

Group B: Saline + mixed meal testPlacebo comparator 2 interventions

Group C: GIP(1-42) + waterActive comparator 1 intervention

Group D: Saline + waterPlacebo comparator 2 interventions

Trial outcomes

Primary outcomes

Postprandial systolic blood pressure change (delta SBP)

The mean difference between postprandial systolic blood pressure-change (delta SBP) during tilt test following infusion of GIP(3-30)NH2 compared to infusion of placebo.

Time frame

From -35 to 50 minutes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Gentofte, Copenhagen

Lead sponsor

Source ClinicalTrials.gov

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