Effects of Infertility and Assisted Reproductive Technology on Sexual Function and Behavior

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-44
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre

About this trial

This cross-sectional observational study examines how infertility and the use of assisted reproductive technology (ART) are related to sexual function and sexual behaviors in women seeking fertility treatment. Infertility and the stress of ART may be associated with changes in sexual desire, satisfaction, and activity. The purpose is to better understand these associations to support the sexual health and overall well-being of women undergoing fertility care.

Women who are assigned female at birth, under 45 years old, diagnosed with infertility, and attending appointments at the MUHC Reproductive Centre are invited to take part. Participants will be asked to complete an anonymous questionnaire while waiting for their clinical visit. The questionnaire includes the validated Female Sexual Function Index (FSFI), which measures different aspects of sexual function, and additional questions about sexual activities, such as frequency of intercourse and other behaviors before and after fertility treatments.

Participants will not provide any identifying information. Completed questionnaires will be placed in a secure collection box to protect confidentiality.

Data from approximately 500 participants will be analyzed to explore how infertility type (primary vs. secondary), duration of infertility, and the number of unsuccessful ART cycles relate to sexual function and behavior. Findings from this study may help healthcare providers better recognize and address the sexual health concerns of women with infertility.

This study is approved by the McGill University Health Centre Research Ethics Board (REB #2025-11459).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Assigned female at birth.

Self-identify as a woman.

Age 18-44 years.

Diagnosis of infertility.

Disqualifiers

Assigned male at birth.

Age 45 years or older.

Sexual practices that do not allow for the possibility of conception (e.g., same-sex relationships without use of assisted reproductive technologies).

Seeking oocyte cryopreservation.

Trial population

This study will include women assigned female at birth, aged 18-44 years, who are seeking fertility treatment at the MUHC Reproductive Centre and have a diagnosis of infertility. Participants must self-identify as women. Individuals assigned male at birth, age 45 or older, seeking oocyte cryopreservation, or whose sexual practices do not allow for conception without assisted reproductive technologies will be excluded. Participation is voluntary and anonymous.

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

500 Participants
are grouped into 1 trial group
Group A: Observational Infertility Cohort

Trial outcomes

Primary outcomes

1

Female sexual function

Female sexual function as assessed using the validated Female Sexual Function Index (FSFI), which evaluates desire, arousal, lubrication, orgasm, satisfaction, and pain. Higher scores indicate better sexual function.

Time frame
Day 1
2

Sexual Behaviour

Self-reported sexual behaviors, including intercourse frequency (pre- and post-fertility treatment), oral sex, anal sex, masturbation, and other sexual practices, as assessed by the anonymous questionnaire.

Time frame
Day 1

Secondary outcomes

Other outcomes

Sponsors and contacts

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