Prediabetes is a metabolic condition associated with increased risk of type 2 diabetes and cardiovascular disease. Intermittent fasting (IF) has emerged as a potential dietary intervention to improve metabolic health, yet comparative evidence among different IF patterns remains limited.
This randomized controlled trial aims to evaluate the effects of three intermittent fasting regimens-5:2 fasting, alternate-day fasting, and time-restricted feeding-compared with a control diet on metabolic parameters, inflammatory markers, body composition, and nutrigenomic profiles in adults with prediabetes.
Patients with prediabetes, defined according to ADA criteria (fasting plasma glucose 100-125 mg/dL or 2-hour postprandial glucose 140-199 mg/dL).
Willing to follow the fasting/diet intervention protocol for 4-6 weeks (depending on the study duration).
Signing informed consent and willing to be randomized into one of 3 intervention groups (Monday-Thursday Fasting/5:2, Alternate-Day Fasting/ADF, or Time-Restricted Fasting/IF).
Diagnosis of type 2 diabetes mellitus.
Currently undergoing antidiabetic drug therapy (e.g., metformin, sulfonylurea, insulin).
Has a severe chronic disease (kidney failure, liver failure, heart failure, or eating disorder).
Pregnancy or breastfeeding.
Parallel
Diet
BehavioralIntermittent Fasting
Metabolic Profile
Change in Fasting Plasma Glucose (mg/dL)
Lipid Profile
Concentration Changes of Total Cholesterol
Lipid Profile
Concentration Changes of LDL
Lipid Profile
Concentration Changes of HDL
Lipid Profile
Concentration Changes of Triglycerides
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Muhammad Aron Pase
Lead sponsor
Universitas Sumatera Utara
Sponsor institution
This trial is not recruiting at the moment. You can still explore other options: