Effects of Isocapnic Respiratory Muscle Endurance Training in Healthy Adults
ConditionHealthy Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorUniversity of British Columbia
About this trial
Respiratory muscle training (RMT) strengthens breathing muscles and may improve exercise performance and reduce breathlessness. However, different training methods and devices create controversy in the field. Two main types of RMT exist: inspiratory muscle training (IMT) and respiratory endurance training, like voluntary isocapnic hyperpnea (VIH). While IMT is well-studied, the impact of VIH on breathlessness remains unclear. This study will use the Canadian-developed BreathWayBetter device to examine how 5 weeks of VIH affects breathing discomfort and muscle function. Findings may help personalize RMT for athletes and clinical patients, improving respiratory care and exercise tolerance.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18-55 years of age (inclusive)
Male or Female (biological sex)
Body mass index greater than 18 or less than 30 kg/m2
Normal pulmonary function: FEV1/FVC > 0.70 and FEV1 ≥ 80%
Disqualifiers
Currently smoke, vape, or use cannabis, or have a history of frequent smoking, vaping or cannabis use
History of, or current symptoms of cardiopulmonary (i.e., lung and/or heart) disease (excluding controlled asthma)
Heart problem; a serious infection within the body; a neuromuscular (nerve to muscle) or musculoskeletal (muscle, ligament and/or bone) disorder; or other health problem that will be made worse with exercise testing
Contraindications to exercise testing defined as anything that would prevent exercise under proper and safe conditions (e.g. a problem with the heart or lungs, muscle or bone injury, a serious infection)
Trial design
Design model
Parallel
Treatments tested in this trial
Respiratory muscle endurance training
Other interventionRespiratory muscle endurance training program over 5 weeks.
Sham respiratory muscle endurance training
Other interventionRespiratory muscle endurance training program over 5 weeks following a sham training procedure that is meant to elicit no physiologic changes.
Treatment groups
32 Participants
are divided into 2 treatment groupsGroup A: Low frequency and intensity trainingSham comparator 1 intervention
Group B: Progressive high frequency and intensity trainingActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change from baseline in dyspnoea ratings on the 0-10 Borg scale after respiratory endurance training
Dyspnoea ratings on the 0-10 Borg scale will be recorded during and after incremental cardiopulmonary exercise testing on a stationary cycle ergometer. Dyspnoea ratings will then be compared between the pre- and post-intervention visits.
Time frame
Up to 7 weeks2
Difference in maximal oxygen consumption (VO2peak) following high intensity training program compared to sham comparator program.
Changes in peak oxygen consumption (VO2peak) will be measured during an incremental cardiopulmonary exercise test on a stationary cycle ergometer and compared between intervention conditions.
Time frame
Up to 7 weeksSecondary outcomes
1
Correlation between changes from baseline in maximal oxygen consumption (VO2peak) and changes from baseline in dyspnoea ratings on the 0-10 Borg scale following respiratory endurance training.
Peak oxygen consumption (VO2peak) in units of ml/kg/min and dyspnoea ratings measured on the 0-10 Borg scale will be measured during an incremental cardiopulmonary exercise test on a stationary cycle ergometer and compared between the pre- and post-intervention visits.
Time frame
Up to 7 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of British Columbia
Lead sponsor
Mitacs
Collaborator
Source ClinicalTrials.gov