Studies have shown that aging can promote a variety of pathological processes, such as myocardial remodeling and cardiac dysfunction caused by ischemia-reperfusion injury and pressure load. Previous studies found that the level of circulating beta-hydroxybutyric acid decreased significantly with age. It has been reported that the ketogenic diet reduces the occurrence of tumors and neurodegenerative diseases in mice, improves motor coordination and endurance, and ultimately extends life span. Current research results have confirmed that ketone bodies have multiple mechanisms to exert beneficial effects on cardiovascular diseases. However, the effect of age-related cardiovascular disease has not been reported.
In order to further clarify the role of beta-hydroxybutyric acid in age-related cardiovascular diseases, find new intervention targets for elderly cardiovascular diseases, and develop new effective prevention and treatment measures for elderly cardiovascular diseases. We will further investigate this hypothesis by establishing a clinical cohort of the elderly population.
Age: 65~80 years old.
The subjects are in good health, and no history of chronic diseases.
Have used immunosuppressants or hormone drugs in the past six months.
There has been a significant change in diet within the past month.
Having digestive tract surgery within one year.
Severe liver dysfunction (alanine aminotransferase level > 3.0 upper limit of normal).
Single group
Ketone ester
Other interventionKetoneAid Ke4 Pro Ketone Ester：20ml, tid po
T cell senescence level (Protein 53、Protein 21 and Protein 16)
Expression of protein 53、protein 21 and protein 16 in human plasma used by western blot.
Circulating inflammatory factor levels (monocyte chemoattractant protein-1 and interleukin-6)
Expression of monocyte chemoattractant protein-1 and interleukin-6 in human plasma used by enzyme linked immunosorbent assay.
Ankle-brachial index
The ankle-brachial index value was measured by dopplex ankle-brachial index detector.
Ejection fraction (EF) levels
Use cardiac echocardiography to assess the ejection fraction level
NT-proBNP level
NT-proBNP level was used by chemiluminescence immunoassay.
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