About this trial
Participants will complete six sessions, including one familiarization and baseline session followed by five experimental conditions: control (no supplementation), placebo, L-tyrosine, caffeine, and combined L-tyrosine plus caffeine. The experimental conditions will be performed in a randomized, counterbalanced crossover design with a washout period of at least 72 hours between sessions. Resting physiological and cognitive assessments will be performed during the familiarization session, while biochemical, cognitive, and boxing-specific performance assessments will be conducted before and after each experimental session.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
None
Trial design
Crossover
Treatments tested in this trial
Placebo
Dietary supplementPlacebo solution matched in taste and volume to active supplements.
L-Tyrosine
Dietary supplementL-tyrosine at 150 mg/kg body weight administered 60 minutes before exercise.
Caffeine
Dietary supplementCaffeine at 5 mg/kg body weight administered 60 minutes before exercise.
L-tyrosine + Caffeine
Dietary supplementCombined L-tyrosine (150 mg/kg) and caffeine (5 mg/kg) administered 60 minutes before exercise.
Treatment groups
Trial outcomes
Primary outcomes
Stroop Test Performance
Cognitive performance assessed using the Stroop test, including reaction time and accuracy.
Secondary outcomes
BDNF Levels
Serum brain-derived neurotrophic factor levels measured before and after exercise.
Oxidative Stress Markers
Serum levels of total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), superoxide dismutase (SOD) activity, and glutathione peroxidase (GPx) activity will be measured.
Sponsors and contacts
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Inonu University
Lead sponsor
Ataturk University
Collaborator
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