Health TrialsbyHealthPanel

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

ConditionsHyperglycaemia (Non Diabetic)Prediabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-65
SponsorUniversity of Arkansas

About this trial

We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1. Males and females ages 40-65 years.

2. BMI 25 to ≤40 kg/m2 (or body fat % ≥25% in males or ≥36% in females)

3. Capable of providing informed consent.

4. COVID-19 negative and/or asymptomatic.

Disqualifiers

1. Participant who does not/will not eat animal protein sources.

2. Allergy to wheat, soy, or common ingredients in plant-based protein products.

3. Body mass index <25 kg/m2 or >40 kg/m2.

4. Hemoglobin <10g/dL at screening.

Trial design

Design model

Crossover

Treatments tested in this trial

  • Lean Pork vs Plant-Based Protein

    Other intervention

    Participants will eat prepared study meals for three days that have either protein sourced from lean pork or plant-based sources.

Treatment groups

20 Participants
are divided into 2 treatment groups
Group A: High Quality Protein Intake - Lean PorkActive comparator 1 intervention
Group B: Low Quality Protein Intake - Plant-BasedActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Muscle Protein Synthesis

Mixed muscle protein synthesis expressed as the fractional synthetic rate.

Time frame
24 hours
2

Whole Body Protein Balance

Amount of net protein gained per unit of time.

Time frame
24 hours

Secondary outcomes

1

Whole Body Protein Synthesis

Amount of protein produced per unit of time.

Time frame
24 hours
2

24-hour Mean Glucose

Derived from continous glucose monitor data.

Time frame
24 hours

Other outcomes

1

Whole Body Protein Breakdown

Amount of protein broken down per unit of time.

Time frame
24 hours
2

Whole Body Protein Flux

Amount of protein turnover per unit of time.

Time frame
24 hours
3

Glucose Regulation and Homeostasis

Derived from continuous glucose monitor data.

Time frame
24 hours

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Arkansas

Lead sponsor

National Pork Board

Collaborator

Source ClinicalTrials.gov
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