Effects of LH and FSH on Metabolic Regulation in Cumulus Cells
ConditionUnrecognized Condition
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age35-40
SponsorKaohsiung Veterans General Hospital.
About this trial
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 35-40 years
BMI 18-30 kg/m2
planning to undergo IVF cycles
Disqualifiers
Primary ovarian insufficiency
history of oophorectomy
receiving oocyte donation
Chromosome anomaly
Trial design
Design model
Parallel
Treatments tested in this trial
FSH and LH
DrugIn the study group, participants receive FSH and LH in IVF cycle
FSH
DrugIn the control group, participants receive FSH alone in IVF cycle
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: combined FSH and LHExperimental treatment 1 intervention
Group B: FSH aloneActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
oxygen consumption rate of mitochodria (%)
to assess mitocondrial function in cumulus cells
Time frame
through study completion, an average of 3 year2
Live birth rate (%)
a viable infant after 24 weeks of gestation
Time frame
through study completion, an average of 3 yearSecondary outcomes
1
Amount of ATP production (moles/min) of mitochodria
to assess mitocondrial function in cumulus cells
Time frame
through study completion, an average of 3 year2
Clinical pregnancy rate (%)
the presence of a fetal heartbeat detected via transvaginal sonography at 6-7 weeks of gestation
Time frame
through study completion, an average of 3 yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov