Effects of Mixed Nut Consumption on Satiety and Weight Management
ConditionSatiety
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorSan Diego State University
About this trial
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18-55 years old
BMI 27-40
Disqualifiers
Smoker
Pregnant woman
Required dietary supplement use
Required medication of metabolic disorders
Trial design
Design model
Parallel
Treatments tested in this trial
Pretzels
Other interventionSubjects consume 240 kcal of pretzels daily for 16 weeks.
Mixed nuts
Other interventionSubjects consume 240 kcal of mixed nuts daily for 16 weeks.
Treatment groups
56 Participants
are divided into 2 treatment groupsGroup A: PretzelsActive comparator 1 intervention
Group B: Mixed nutsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change of Satiety
Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest
Time frame
0, 20, 40, 60, 90 and 120 minutes post snack consumption2
Change of glucose level
Glucose level will be examined using glucose analysis
Time frame
Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption3
Change of insulin level
Insulin level will be examined using an ELISA biochemical method
Time frame
Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption4
Change of cholesterol levels
Cholesterol levels will be examined using a biochemical method
Time frame
8 weeks and 16 weeks post daily consumptionSecondary outcomes
1
Change of microbiome
Diversity of microbiome will be analyzed in fecal samples
Time frame
8 weeks and 16 weeks post daily consumptionSponsors and contacts
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Source ClinicalTrials.gov