Health Trials

Effects of N-Acyl Taurines on Incretin Levels in Healthy Subjects

ConditionCardiometabolic Conditions
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity Hospital, Gentofte, Copenhagen

About this trial

This study is an investigator-initiated, randomised, double-blind, placebo-controlled, cross-over human trial investigating the effect of arachidonoyl-taurine (C20:4-taurine) and oleoyl-taurine (C18:1-taurine) on GLP-1 secretion during fasting and feeding.

Eligibility criteria

Qualifiers

Age between 18 and 45 years

Body mass index between 18.5-27 kg/m2

Informed consent

Weight stable in the past 3 months

Disqualifiers

Regular tobacco smoking or use of other nicotine-containing products

Allergy or intolerance to ingredients included in the test compounds or standardised meals

Glycated haemoglobin (HbA1c) >48 mmol/mol

Anaemia (haemoglobin below 8.3 mmol/L)

Trial design

Treatments tested in this trial

  • Placebo: First dose at 0 hours
  • Arachidonoyl-taurine: First dose at 0 hours
  • Oleoyl-taurine: First dose at 0 hours
  • Liquid meal and second dose of placebo at 3 hours
  • Liquid meal and second dose of OLE-T at 3 hours
  • Liquid meal and second dose of ARA-T at 3 hours

Treatment groups

18 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

University Hospital, Gentofte, Copenhagen

Lead sponsor

University of Copenhagen

Collaborator

Source ClinicalTrials.gov