Effects of Negative Pressure Ventilation on Right Ventricular Function in Cardiological Patients

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKarlsburg Hospital

About this trial

Patients receives induction of general anesthesia for interventional tricuspidal clipping and standard monitoring for this procedure including arterial and central venous line and transesophageal ultrasound. A cuirass for extrathoracal negative pressure ventilation is placed onto the chest but not switched on. During usual positive pressure ventilation a ventilatory, a hemodynamic and a 3D full volume ultrasounddataset of the right and left ventricle is recorded and severity of tricuspidal regurgitation examined. Afterwards negative pressure ventilation is started and positive pressure ventilation reduced as far as possible without reduction of tidal volumes. The same dataset of ventilation, hemodynamics and ultrasound is collected again during negative pressure ventilation. Afterwards the cuirass gets removed, study finished and everything proceeds as during standard procedure.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patients planned for tricuspidal clipping

Disqualifiers

ventilatory of hemodynamic instability

fitting of cuirass not possible

unavailability of examiner

Trial population

All patients for tricuspidal clipping without an exclusion criterium

Trial design

Design model

Other

Time perspective

Other

Treatments tested in this trial

  • Negative Pressure Ventilation

    Device

    Substitution of positive pressure ventilation by negative pressure ventilation

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

stroke volume index

transesophageal ultrasound measurement

Time frame
1 minute

Secondary outcomes

1

RVEF

transesophageal ultrasound measurement

Time frame
1 minute
2

LVEF

transesophageal ultrasound measurement

Time frame
1 minute
3

volumes of chambers

transesophageal ultrasound measurement

Time frame
1 minute
4

strain

transesophageal ultrasound measurement

Time frame
1 minute

Other outcomes

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: