This Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults with Sleep deprivation: A Proof-of-Concept Study aims to investigate the effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on memory and cognitive function in adults experiencing sleep deprivation(SD). Given the known impact of SD on cognitive performance, this study seeks to explore whether NSCLD, as a non-invasive intervention, can mitigate the cognitive impairments associated with SD.
College student ≥18 years, all of whom have passed a standardized entrance examination;
No failed exams during the course of study;
Sleep deprivation;
In good health, with no mental or psychological disorders;
Pregnant or breastfeeding women.
Presence of acute or chronic medical conditions (e.g., severe hypertension, diabetes, cardiovascular disease) that could confound the results.
History of craniocervical trauma or surgery.
Current use of sedative or anxiolytic medications that could influence sleep or cognitive function.
Crossover
Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD)
DeviceParticipants will be randomly assigned to either an intervention group receiving NSCLD or a control group receiving a sham-intervention treatment. Cognitive function will be assessed using standardized tests before and after the intervention.
sham-intervention treatment
DeviceParticipants will be randomly assigned to either an intervention group receiving NSCLD or a control group receiving a sham-intervention treatment. Cognitive function will be assessed using standardized tests before and after the intervention.
Digit Span Test
Evaluate memory function. 1 point for each correct string of numbers. Total score: forward score + backward score. Higher scores mean a better outcome.
Montreal Cognitive Assessment (MoCA)
The maximum score is 30 points. ≥26 points is normal. Higher scores mean a better outcome.
Changes in anxiety, stress, irritability, etc. before and after instant massage
use Multidimensional VAS Battery. 0 points are "not at all", and 100 points are "extremely strong" (points 0- 100)
Brain metabolic markers and other metabolic indicators
Collect blood for analysis of Aβ42/40, T-Tau, p-tau217, Plasma cortisol, Salivary α-Amylase and β-Endorphin.
EEG power in alpha, beta, delta and theta band
Measure the power of different frequency bands of EEG and compare the changes.
Heart rate variability (HRV)
Analyze the different indicators of HRV, including RMSSD, LF, HF, LF/HF ratio, SDNN, etc.
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Tao Liu
Lead sponsor
The George Institute
Sponsor institution
Tianjin Medical University General Hospital
Collaborator
Xuanwu Hospital, Beijing
Collaborator
