Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Sao Paulo

About this trial

The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), in reducing halitosis in individuals with periodontal disease and type 2 diabetes mellitus. The main question it aims to answer is: aPDT treatment is more effective in treating halitosis? aPDT treatment is more effective in periodontitis? Researchers will compare aPDT treatment to conventional treatment (scaling and root planning and tongue scraper) to see if aPDT has additional effects in reducing halitosis and improving periodontal health.

* Participants will be asked to visit the clinic once a week for exam and treatment during 1 month. * After active treatment they will be asked to come to maintenance and control visits once a month until 6 months.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients diagnosed with type 2 diabetes mellitus according to the 2019 WHO criteria

Stage 3 or 4 periodontitis

No periodontal treatment in the previous 12 months

a minimum of 20 remaining teeth.

Disqualifiers

Smokers

Alcohol-dependent individuals

Pregnant or lactating women

Patients with renal disorders

Trial design

Design model

Parallel

Treatments tested in this trial

  • Scaling and root planing

    Procedure/Surgery

    Mechanical removal of biofilm in periodontal pockets and tongue

  • Photodynamic Therapy with Conventional Methylene Blue

    Procedure/Surgery

    Antimicrobial photodynamic therapy in periodontal pockets and tongue

Treatment groups

32 Participants
are divided into 2 treatment groups
Group A: aPDT - antimicrobial photodynamic therapyExperimental treatment 1 intervention
Group B: ControlActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Halitosis

Measurement of oral volatile compounds by gas chromatography

Time frame
From enrollment to the end of treatment at 6 months

Secondary outcomes

1

Probing depth

Measurement in milimeters of the periodontal pocket

Time frame
From enrollment to the end of treatment at 6 months
2

Clinical Attachment level

Measuremet in milimeters from cementoenamel junction to bottom of the pocket

Time frame
From enrollment to the end of treatment at 6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.