Health TrialsbyHealthPanel

Effects of Petroleum Compounds on Psychological Health and Cognitive Functions

ConditionCognitive Deterioration
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-50
SponsorAssiut University

About this trial

Over the last decade, awareness of the effects of hydrocarbon fuels on neurodegenerative disorders has increased significantly, as they are ubiquitous environmentally toxic chemicals that affect the central nervous system and result in irreversible neuronal damage, as many hydrocarbons can cross the blood-brain barrier through multiple pathways and cause direct toxicity.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Workers in direct contact with petroleum compounds in petroleum stations.

Working for at least 8 continuous hours daily for at least 2 years before enrollment in the study.

Participants have willingness to participate and have no history for substance abuse

Disqualifiers

Working for less than 2 years with interrupted exposure.

The exposure of workers to petroleum compounds is indirect.

History of psychological and neurodegenerative diseases before starting this job.

Patients with medical conditions like renal or cardiovascular diseases.

Trial population

Petrol station workers at Assiut fuel stations with exposure time of 8 continuous hours for at least 2 years

Trial design

Design model

Case-only

Time perspective

Cross-sectional

Treatments tested in this trial

  • whey protien

    Dietary supplement

    Whey, the supernatant of yogurt and a byproduct of cheese, is rich in protein and consists of β-lactalbumin, α-lactoglobulin, immunogloblin, bovine serum albumin, and other minor proteins. Whey protein is a globally consumed food material and is well known for its health benefits

Treatment groups

196 Participants
are divided into 1 treatment group
Group A: petrol station workers1 intervention

Trial outcomes

Primary outcomes

1

Effects of petroleum compounds on psychological health and cognitive functions of petrol station workers in Assiut

for psychological assessment through symptom check list 90 (revised) and cognitive function through the Mini Mental State Examination (30 points: 25-30: normal; 21-24: mild cognitive impairment; 10-20: moderate; and 0-9: severe) and Wecksler memory scale (higher score indicates better performance, while lower score indicates memory impairment)

Time frame
1 year
2

To explore the relation between the level of petroleum hydrocarbon metabolites and the severity of psychological heath and cognitive functions disturbance of petrol station workers

urinary metabolites for BTEX through GS-MS

Time frame
1 year
3

To explore the role of supplements with whey protein in ameliorating these effects

20 g of whey protein 3 times per week for 8 weeks will be given to workers with cognitive difficulties

Time frame
1 year

Secondary outcomes

1

To assess the relationship between the psychological effects, cognitive functions, and nutritional status of petroleum station workers

relationship between nutritional status, psychological symptoms, and cognitive difficulties through statistics

Time frame
1 year

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: