Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension

ConditionEssential Hypertension

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age65-85

SponsorYi Yang

About this trial

The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1) Age ≥65 years and ≤85 years, regardless of gender;

2) History of essential hypertension and clinical systolic blood pressure ≥ 140 mmHg, regardless of whether they are receiving antihypertensive medication;

3) Willing to participate and sign the informed consent.

Disqualifiers

1) Secondary hypertension;

2) Clinical blood pressure ≥ 180/110 mmHg or 24-hour mean arterial pressure ≥ 170/100 mmHg;

3) Severe organ dysfunction or failure;

4) Severe hematologic disorders or significant coagulation abnormalities;

Trial design

Design model

Parallel

Treatments tested in this trial

Remote ischemic conditioning
Procedure/Surgery
Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by the inflation of an automated cuff to the pressure rising by 20 mmHg from baseline systolic pressure. RIC will be conducted twice daily for 7 days.
Sham remote ischemic conditioning
Procedure/Surgery
Sham-RIC is performed in the same way as the treatment group except that the blood pressure cuff is inflated to 60 mmHg, which produces mild pressure sensations but has no blocking impact on blood flow.

Treatment groups

158 Participants

are divided into 2 treatment groups

Group A: RIC groupActive comparator 1 intervention

Group B: Sham RIC groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Mean systolic blood pressure

Difference in mean value of systolic blood pressure during RIC/sham-RIC between two groups.

Time frame

0-7 days

Secondary outcomes

Mean diastolic blood pressure

Difference in mean value of diastolic blood pressure during RIC/sham-RIC between two groups.

Time frame

0-7 days

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yi Yang

Lead sponsor

The First Hospital of Jilin University

Sponsor institution

Source ClinicalTrials.gov

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