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Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT)

ConditionIschemic Preconditioning
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorFirst Affiliated Hospital Xi'an Jiaotong University

About this trial

The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Aged 18 to 45 years;

Be in good health;

Consent to participate in the clinical trial and sign the informed consent form.

Disqualifiers

Abnormal results in biochemical checks and physiological indicators.

Cardiovascular and cerebrovascular diseases: hypertension, coronary heart disease, congenital heart disease, cerebrovascular alterations, etc.

Endocrine diseases: diabetes, thyroid disorders, etc.

Hematologic diseases: anemia, paroxysmal hemoglobinuria, primary thrombocytosis, etc.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Remote ischaemic preconditioning

    Device

    The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days.

Treatment groups

80 Participants
are divided into 3 treatment groups
Group A: Group A (high-frequency group )Experimental treatment 1 intervention
Group B: Group B (low-frequency group )Experimental treatment 1 intervention
Group C: no-intervention control groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Changes in the expression levels of cardiovascular disease-related molecules

Changes in the expression levels of cardiovascular disease-related molecules between participants in group A (intermediate RIPC training, once a day) or B (intense RIPC training, twice a day)

Time frame
Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Secondary outcomes

1

Longitudinal within-group changes in the expression of cardiovascular disease-related molecules

Longitudinal within-group changes in cardiovascular disease-related molecular biomarker expression across different study time points

Time frame
Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training
2

Change of blood pressure

Changes in blood pressure at different remote ischemic preconditioning training time points, measured with sphygmomanometer.

Time frame
Baseline (before training), during the training session (day1-7), 7th day after the end of training.
3

Change of heart rates

Changes in heart rates at different remote ischemic preconditioning training time points, measured with stopwatch.

Time frame
Baseline (before training), during the training session (day1-7), 7th day after the end of training
4

Incidence of adverse events

Incidence of adverse events related to remote ischemic preconditioning training. The adverse events were decided according to the medical records.

Time frame
During day 1 to 7 of training.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

First Affiliated Hospital Xi'an Jiaotong University

Lead sponsor

Source ClinicalTrials.gov
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