Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age50-65
SponsorUniversity of Sao Paulo
About this trial
The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH). The main research questions are:
* Does the intensity of RT impact blood pressure (BP) in postmenopausal women with SAH? * How does RT intensity affect heart rate (HR) and their variability (HRV), endothelial function (EF), and nitric oxide (NO) biomarker synthesis in this population? * What are the effects of RT intensity on affectivity and rate of perceived exertion (RPE)?
Researchers will compare two different intensities of RT (60% of the load for 1 repetition maximum \[1RM\] and 80% of 1RM) to determine their effects on the mentioned cardiovascular and perceptual parameters.
Participants will:
In the acute experiment:
* Perform the same RT session in a crossover design, training with 60% of 1RM in one condition and 80% of 1RM in another condition * Have BP, HR, and HRV measured before, immediately after, and for one hour post-session * Report affectivity before each session and at the end, along with RPE
In the chronic experiment:
* Be randomized into two groups: one training with 60% of 1RM and the other with 80% of 1RM * Undergo a 10-week intervention period with evaluations before, during, and after the intervention * Have BP, HR, affective responses, and RPE measured at multiple time points * Have EF, HRV, and salivary concentrations of NO biomarkers assessed before and after the intervention
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Women with 50 to 65 old years;
Postmenopausal diagnosis (amenorrhea for 12 months or more);
Previous diagnosis of hypertension and treat with medications;
Physically inactive.
Disqualifiers
History of other cardiovascular problems (heart failure, heart attack, stroke, etc);
Grade II obesity (BMI ≥ 35 kg/m²);
Medications (beta-blockers and/or non-dihydropyridine calcium channel blockers);
Systolic blood pressure at rest above 160 mmHg and/or dyastolic blood presure above 105 mmHg;
Trial design
Design model
Parallel
Treatments tested in this trial
Resistance training
BehavioralThe exercises will be the same in both stages: squat, bench press, stiff, rowing, hip thrust and shoulder press. Futhermore, the rest interval (2 minutes) and the exercise order (alterning upper and lower limbs) also will be the same in the stages. In the chronic experiment, the resistance training will be carried for 10 weeks with 2 weekly sessions in alternate days. The sets in both groups will be carried close to muscle failure. The difference between groups is the intensity, who reflects the repetition zone. The 80%1RM group will be perform 8-10 repetitions per set, while the 60%1RM group will be perform 18-20 repetitions.
Treatment groups
24 Participants
are divided into 2 treatment groupsGroup A: 80% of 1 repetition maximumActive comparator 1 intervention
Group B: 60% of 1 repetition maximumActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Values of systolic and diastolic blood pressure (mmHg)
This measurement will be assessed in both stages. In the acute phase, this measurement will be performed on the participant before, after and up to one hour after the end of the training session. In the chronic phase, this measure will be performed in participant after a rest in a quiet room with temperature controlled before (baseline) and after 10 week of intervention. Futhermore, along the intervention these measure will be performed before and after training sessions.
Time frame
Up to end of study data collection (both stages), i.e, assesed up to 1 yearSecondary outcomes
1
Values of heart rate variability (ms)
This measurement will be assessed in both stages. In the acute phase, this measurement will be performed on the participant before, after and up to one hour after the end of the training session. In the chronic phase, this measure will be performed in participant after a rest in a quiet room with temperature controlled before (baseline) and after 10 week of intervention. Futhermore, along the intervention these measure will be performed before and after training sessions.
Time frame
Up to end of study data collection (both stages), i.e, assesed up to 1 year2
Endothelial function (Flow mediated dilatation %)
This measurement will be performed before acute experiment (baseline) and after 10 week intervention (end of chronic experiment) in a quiet room with controlled temperature.
Time frame
Up to end of chronic experiment (baseline and post-intervention values), assesed up to 1 year3
Salivary concentrations of nitric oxide (mmol/L)
This measurement will be performed before acute experiment (baseline) and after 10 week intervention (end of chronic experiment).
Time frame
Up to end of chronic experiment (baseline and post-intervention values), i.e, assesed up to 1 year4
Rate of perceived exertion (scale from 1 to 10)
This measurement will be performed after all training sessions, i.e, in both stages. The participants will be remembered the meanings of the scale.
Time frame
Up to end of study data collection (both stages), i.e, assesed up to 1 yearSponsors and contacts
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Source ClinicalTrials.gov