About this trial
Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and/or comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
English as a native or primary language
Adults with stroke who are at least 6 months post-onset
Disqualifiers
History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease
History of a learning disability that significantly impacted language development, such as developmental language disorder
Insufficient stamina to participate in the protocol
Trial design
Single group
Treatments tested in this trial
Criterion-learning practice
BehavioralThe experiments will be presented on a computer. On each criterion-learning trial, a picture is presented and the participant is asked to try to produce the name for the object with or without a cue. Correct-answer feedback is provided. Criterion learning involves presenting a block of items in fixed order, and on each trial, the experimenter or a voice-recognition component will code the response during the trial as correct/incorrect. When the item reaches its assigned criterion level, it is dropped from further training in a session.
Treatment groups
Trial outcomes
Primary outcomes
Trained naming items
Confrontation naming task that involves trained items
Other outcomes
Trained naming items pupillometry
Pupil size during naming
Sponsors and contacts
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Albert Einstein Healthcare Network
Lead sponsor
Thomas Jefferson University
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
This trial is not recruiting at the moment. You can still explore other options: