Effects of Training With a Pressure Cuff on Cellular Energy Activity
ConditionPhysical Deconditioning
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSpital Thurgau AG
About this trial
This study investigates low-load, cuff-assisted training to improve mitochondrial capacity. The intervention is carried out using automated pressure cuffs, applying an individualized pressure of 70% of the limb occlusion pressure. This approach reflects the current scientific consensus for safe and effective use in clinical populations.
Within a rehabilitation setting, two training modalities are compared: intermittent strength training and alternating continuous endurance training. Muscle oxygen saturation is measured non-invasively using near-infrared spectroscopy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Medically confirmed generalized deconditioning with reduced muscle strength
Medical certification of suitability for functional lower-extremity strength training
Written informed consent after an adequate reflection period
Unstable arrhythmias, myocardial ischemia, symptomatic blood pressure drops or hypertension (>160/100 mmHg despite medication)
Disqualifiers
None
Trial design
Design model
Parallel
Treatments tested in this trial
Application of pressure cuffs during strength training
Diagnostic testPre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups.
Application of pressure cuffs during endurance training
Diagnostic testPre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups
Conventional clinical rehabilitation program without the use of pressure cuffs
Diagnostic testPre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups
Treatment groups
51 Participants
are divided into 3 treatment groupsGroup A: Low-load strength training with intermittent application of pressure cuffsActive comparator 1 intervention
Group B: Low-load endurance training with alternating continuous application of pressure cuffsActive comparator 1 intervention
Group C: Conventional clinical rehabilitation program without the use of pressure cuffsPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Determination of changes in the mitochondrial capacity of skeletal muscle (of the thigh muscle, vastus lateralis; measured non-invasively)
Time frame
From enrollment to the end of treatment at 6 weeks.Secondary outcomes
1
Minimum and maximum oxygen saturation (SmO₂) during application of pressure cuffs (measured via NIRS)
Time frame
From enrollment to the end of treatment at 6 weeks.2
Changes in total hemoglobin (tHb) as a measure of local blood volume (measured via NIRS)
Time frame
From enrollment to the end of treatment at 6 weeks.3
Assessment of subjective functional mobility using the "Lower Extremity Functional Scale" (LEFS) questionnaire
Maximal Score: 80; Minimal Score: 0; Higher Score indicates better functional mobility
Time frame
From enrollment to the end of treatment at 6 weeks.Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: