The purpose of this research is to investigate the effect of transcranial temporal interference stimulation (tTIS) targeting the dorsal anterior cingulate cortex in patients with gambling disorder.
Aged 18-60, male or female, right handed;
With 9 or more years of education, and able to cooperate in completing the questionnaire assessment and behavioural tests.
Meets the DSM-5 diagnostic criteria for gambling addiction;
Previous gambling behaviour of not less than 1 year's duration (at least one gambling session per week or more);
Suffering from severe cognitive dysfunction, such as a history of head trauma, cerebrovascular disease, epilepsy, etc., use of cognitive-promoting medications in the last 6 months;
Other psychoactive substance abuse or dependence in the last 5 years (except nicotine).
Parallel
tTIS on dACC, theta frequency (5 Hz)
DeviceDevice: Transcranial electric stimulation device The first pair of electrodes continuously outputs a current with a frequency of f1 = 2 kHz, while the second pair continuously outputs a current with a frequency of f2 = 2.006 kHz. According to the principle of time-domain coherence, an alternating electric field with a frequency of f2-f1 = 6 Hz can be generated in the target area. The experimental group receives a stimulation intensity of 2mA for 20 minutes. The optimal electrode position and current parameters are determined by using the MIDA head electric field model.
tTIS on dACC, High frequency
DeviceThe first pair of electrodes continuously outputs a current with a frequency of f1 = 2 kHz, while the second pair continuously outputs a current with a frequency of f2 = 2 kHz. The sham group receives a stimulation intensity of 2mA for 20 minutes. The optimal electrode position and current parameters are determined by using the MIDA head electric field model.
Activation of dACC
Activation of dACC is measured with resting-state fMRI and task fMRI.
Activation of decision-making network
Activation of decision-making network is measured with resting-state fMRI and task fMRI connectivity analysis.
The change of impulsivity
The change of impulsivity will be measured by sequential decision-making task.
The change of gambling craving
Gambling craving will be measured by the gambling craving Visual Analog Scale (VAS). The total score of VAS ranged from 0 to 10, in which higher scores mean a higher level of gambling craving.
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