The standard method for localizing non-palpable breast cancer is currently clip localization, its positive margin rate still remains around 20-50%. This study aims to compare the accuracy and efficacy of single vs. combined breast tissue markers in localizing non-palpable breast cancer.
female patients, age≥18 year
A score of ≥ 2 on the Eastern Cooperative Oncology Group scale
Patients pathologically diagnosed with breast cancer by core-needle biopsy, received neoadjuvant treatment and the lesion becomes non-palpable before enrollment.
Patients are willing to undergo breast conserving surgery and have no contraindications to breast conserving surgery
Inflammatory breast cancer or Paget's disease
Breast deformities and other conditions that impact breast conservation success rate
Patients with contraindications to breast-conserving surgery, as well as those with systemic diseases, mental disorders, or other subjective reasons that may affect their ability to participate in the trial. Patients with severe bleeding disorders or coagulation disorders were also excluded.
Pregnancy or lactation
Parallel
Wire-guided localization and marker clip localization
Procedure/SurgeryPositioning guide wire and marker clip in the center of the breast lesion
marker clip localization
Procedure/SurgeryPositioning marker clip in the center of the breast lesion
Marginal positive rate
Proportion of patients with positive margin (intraoperative freezing and postoperative pathological margin tissue showing cancer)
Re-operation rate.
the proportion of patients which have a positive margin and requires a re-operation
The proportion of breast-conserving surgery.
It refers to the proportion of patients who have successfully undergone breast-conserving surgery.
IDFS
Time from surgery to the first occurrence of local, distant disease recurrence, or death.
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