Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorSichuan Provincial People's Hospital

About this trial

Efficacy and safety of amphotericin B and azoles in the treatment of invasive fungal disease

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

There is no age limit, gender is not limited

Patients with invasive fungal disease who are treated with polyene antifungals or azole antifungals should be treated for ≥ 7 days.

Disqualifiers

Patients with incomplete data or other factors affecting the clinical outcome judgement

Patients who are judged by the investigator to be unsuitable to participate in this study.

Trial population

Patients with invasive fungal disease who are treated with polyene antifungals or azole antifungals should be treated for ≥ 7 days.

Trial design

Design model

Other

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

1,000 Participants
are grouped into 2 trial groups
Group A: Treatment with polyene antifungal drugs
Group B: Treatment with azole antifungal drugs

Trial outcomes

Primary outcomes

1

Clinical success rate

Clinical success incudes cure or symptom improvement,which means patients are alive, IFD-related symptoms and signs, radiographic abnormalities improve or disappear completely, and microbiological evidence suggests fungal clearance. The proportion of patients with cured or improved symptoms in the total population was analyzed.

Time frame
The end of treatment, up to 1 year

Secondary outcomes

1

Safety of amphotericin B and azoles

Safety evaluation was mainly based on the incidence of adverse events / adverse reactions in the two groups of patients.

Time frame
During the treatment (1-14 days); the end of treatment (Day 14);Day 28 after the start of treatment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.