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Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain

ConditionAnalgesia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNational Cancer Institute, Egypt

About this trial

Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18 to 65 years.

Male and female sexes.

ASA I-II.,III

Cancer patients undergoing thoracotomy incisions

Disqualifiers

Patient refusal

Known allergy to any of the used drugs

Low platelet count, any coagulation defect

Trial design

Design model

Parallel

Treatments tested in this trial

  • Bupivacaine

    Drug

    Bupivacaine 0.25%

  • Bupivacaine + Magnesium

    Drug

    Bupivacaine 0.25% + Magnesium

  • Bupivacaine + Dexmedetomidine

    Drug

    Bupivacaine 0.25% + Dexmedetomidine

Treatment groups

60 Participants
are divided into 3 treatment groups
Group A: Erector spinae plane block with 0.25% bupivacaineActive comparator 1 intervention
Group B: Erector spinae plane block with 0.25% bupivacaine and MagnesiumExperimental treatment 1 intervention
Group C: Erector spinae plane block with 0.25% bupivacaine and DexmedetomidineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Total postoperative morphine consumption

Total dose of morphine needed postoperatively in the first 24 h

Time frame
First 24 hours postoperatively

Secondary outcomes

1

Time to first postoperative rescue analgesia.

Time to first postoperative rescue analgesia.

Time frame
First 24 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National Cancer Institute, Egypt

Lead sponsor

Source ClinicalTrials.gov
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