Efficacy of Remifentanil in Preventing Emergence Agitation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

About this trial

The primary aim of the study was to test the hypothesis that remifentanil administered for analgesia prevents emergence agitation more effectively than fentanyl and N2O in patients undergoing rhinoplasty who received desflurane as an inhaled anesthetic agent. The secondary aim of the study was to compare the demographic data, intraoperative and postoperative hemodynamic data, surgical time and modified Aldrete score of patients who received different intraoperative analgesia methods.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

Patients with a known history of allergy to the drugs to be administered in the study, ASA III and above, body mass index (BMI) 35>kg/m2, younger than 18 years of age, any problems that would prevent general anesthesia in the preoperative evaluation (upper respiratory tract infection, etc.), and those who did not agree to participate in the study were excluded from the study.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Remifentanil

    Drug

    remifentanil infusion

  • N2O

    Drug

    Use of N2O for analgesia

  • Fentanyl

    Drug

    Use of Fentanylfor analgesia

Treatment groups

99 Participants
are divided into 3 treatment groups
Group A: group 1 RemifentanilyActive comparator 1 intervention
Group B: group 2 N2OActive comparator 1 intervention
Group C: group 3 FentanlyActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Richmond Agitation-Sedation Scale (RASS)

* 4 Combative, violent, danger to staff * 3 Pulls or removes tube(s) or catheters; aggressive * 2 Frequent non-purposeful movement, fights ventilator * 1 Anxious, apprehensive, but not aggressive 0 Alert and calm * 1 Awakens to voice (eye opening/contact) \> 10 seconds * 2 Light sedation; briefly awakens to voice (eye opening/contant) \< 10 seconds * 3 Moderate sedation; movement or eye opening. No eye contact * 4 Deep sedation; no response to voice, but movement or eye opening to physical stimulation * 5 Unarousable; no response to voice or physical stimulation

Time frame
Postoperative care unit 1.second_5. second_15.second

Secondary outcomes

1

mean arterial pressure

mmHg

Time frame
Before induction ,After intubation 1 min,After intubation 5 min, After intubation 15 min After intubation 30 min
2

Heart rate

beats/min

Time frame
Before induction ,After intubation 1 min,After intubation 5 min, After intubation 15 min After intubation 30 min

Other outcomes

Sponsors and contacts

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